光敏感型嵌段聚合物胶束的研究进展.pdfVIP

学兔兔 化 工 进 展 ·2372· CHEMICAL INDUSTRY AND ENGINEERING PROGRESS 2014年第33卷第9期 光敏感型嵌段聚合物胶束的研究进展 余丽丽 ～，汤新景 ( 西安医学院药学院，陕西 西安 710021； 北京大学医学部药学院天然药物及仿生药物国家重点实验室 北京 100191) 摘要：对聚合物结构中常见的光敏感性基团进行了介绍，并根据嵌段共聚物结构设计和光敏感基团的差异，将 光敏感型嵌段聚合物胶束(BCPM)分为侧链变化型、主链断裂型、主链降解型和疏水交联型等几类，并对这几 类BCPM的结构特征及其光刺激下结构的变化进行了对比分析，重点阐明了各类BCPM作为药物载体材料时对 药物的光控包载或释放行为。光敏感型BCPM具有良好的结构可控性和刺激响应能力，通过结构的进一步优化 和研究的不断深入将有望发展成为一类新型的药物靶向输送系统。 关键词：光敏感；嵌段共聚物；胶柬；纳米粒子 中图分类号：0 631．1 文献标志码：A 文章编号：1000—6613(2014)09—2372—08 DoI：10．3969~．issn．1000—6613．2014．09．023 Progress in photo-responsive block copolymer micelles YULili 2 TANGXinjing2 ( Department ofPharmacy，Xi’an Medical University，Xi’an710021，Shaanxi，China； State Key Laboratory ofNatural and Biomimetic Drugs，Peking University，Beijing 100191，China) Abstract：The common group of photo—responsive moieties was introduced in this paper．According to the block copolymer structure and the particularity of photo·responsive moieties，the photo-responsive block copolymer micelles(BCPM)were divided into four kinds，which are side chain change，main chain rupture，main chain degradation，and hydrophobic cross-linking．In addition，the characteristics of these BCPM and the light stimuli structure changes of these micelles were reviewed．Particular attention is paid to light—dependent drug loading process and drug release behavior for drug delivery． Through further structure optimization and research，some photo-responsive BCPM is expected to develop into a new type of drug targeting delivery system