Caffeine Impairs Myocardial Blood Flow Response to Physical Exercise in Patients with Coronary Artery Disease as well as in Age-Matched Controls 英文参考文献.docVIP

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Caffeine Impairs Myocardial Blood Flow Response to Physical Exercise in Patients with Coronary Artery Disease as well as in Age-Matched Controls 英文参考文献.doc

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Caffeine Impairs Myocardial Blood Flow Response to Physical Exercise in Patients with Coronary Artery Disease as well as in Age-Matched Controls 英文参考文献

CaffeineImpairsMyocardialBloodFlowResponseto PhysicalExerciseinPatientswithCoronaryArtery DiseaseaswellasinAge-MatchedControls MehdiNamdar1,TizianoSchepis1,PascalKoepfli1,OliverGaemperli1,PatrickT.Siegrist1, RenateGrathwohl1,InesValenta1,RaphaelDelaloye1,MichaelKlainguti1,ChristopheA.Wyss1, ThomasF.Lu¨scher1,PhilippA.Kaufmann1,2* 1CardiacImaging,UniversityHospital,Zurich,Switzerland,2ZurichCenterforIntegrativeHumanPhysiology(ZIHP),UniversityofZurich,Zurich,Switzerland Abstract Background: Caffeine is one of the most widely consumed pharmacologically active substances. Its acute effect on myocardialbloodflowiswidelyunknown.Ouraimwastoassesstheacuteeffectofcaffeineinadosecorrespondingtotwo cupsofcoffeeonmyocardialbloodflow(MBF)incoronaryarterydisease(CAD). Methodology/PrincipalFindings:MBFwasmeasuredwith 15O-labelledH2OandPositronEmissionTomography(PET)at restandafter supinebicycleexercise incontrols(n=15, meanage 58613years) andin CADpatients (n=15,meanage 6169years).Inthelatter,regionalMBFwasassessedinsegmentssubtendedbystenoticandremotecoronaryarteries.All measurementswererepeatedfiftyminutesafteroralcaffeineingestion(200mg).Myocardialperfusionreserve(MPR)was calculatedasratioofMBFduringbicyclestressdividedbyMBFatrest.RestingMBFwasnotaffectedbycaffeineinboth groups. Exercise-induced MBF response decreased significantly after caffeine in controls (2.2660.56 vs. 2.0260.56, P,0.005), remote (2.4060.70 vs. 1.7860.46, P,0.001) and in stenotic segments (1.9060.41 vs. 1.3860.30, P,0.001). Caffeine decreased MPR significantly by 14% in controls (P,0.05 vs. baseline). In CAD patients MPR decreased by 18% (P,0.05vs.baseline)inremoteandby25%instenoticsegments(P,0.01vs.baseline). Conclusions: We conclude that caffeine impairs exercise-induced hyperaemic MBF response in patients with CAD to a greaterdegreethanage-matchedcontrols. Citation:NamdarM,SchepisT,KoepfliP,GaemperliO,SiegristPT,etal.(2009)CaffeineImpairsMyocardialBloodFlowResponsetoPhysicalExerciseinPatients w