CAMKII Activation Is Not Required for Maintenance of Learning-Induced Enhancement of Neuronal Excitability 英文参考文献.docVIP

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CAMKII Activation Is Not Required for Maintenance of Learning-Induced Enhancement of Neuronal Excitability 英文参考文献.doc

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CAMKII Activation Is Not Required for Maintenance of Learning-Induced Enhancement of Neuronal Excitability 英文参考文献

CAMKIIActivationIsNotRequiredforMaintenanceof Learning-InducedEnhancementofNeuronalExcitability OriLiraz1,2,KobiRosenblum1,2,EdiBarkai1,2 * 1DepartmentofNeurobiology,FacultyofSciences,HaifaUniversity,Haifa,Israel,2DepartmentofBiology,FacultyofSciences,HaifaUniversity,Haifa,Israel Abstract Pyramidal neurons in the piriform cortex from olfactory-discrimination trained rats show enhanced intrinsic neuronal excitabilitythatlastsforseveraldaysafterlearning.Suchenhancedintrinsicexcitabilityismediatedbylong-termreduction in the post-burst after-hyperpolarization (AHP) which is generated by repetitive spike firing. AHP reduction is due to decreased conductance of a calcium-dependent potassium current, the sIAHP. We have previously shown that learning- induced AHP reduction is maintained by persistent protein kinase C (PKC) and extracellular regulated kinase (ERK) activation.However,themolecularmachineryunderlyingthislong-lastingmodulationofintrinsicexcitabilityisyettobe fully described. Here we examine whether the CaMKII, which is known to be crucial in learning, memory and synaptic plasticityprocesses,isinstrumentalforthemaintenanceoflearning-inducedAHPreduction.KN93,thatselectivelyblocks CaMKII autophosphorylation at Thr286, reduced the AHP in neurons from trained and control rat to the same extent. Consequently,thedifferencesinAHPamplitudeandneuronaladaptationbetweenneuronsfromtrainedratsandcontrols remained.Accordingly,thelevelofactivatedCaMKIIwassimilarinpirifromcortexsamplestakenformtrainedandcontrol rats.OurdatashowthatalthoughCaMKIImodulatestheamplitudeofAHPofpyramidalneuronsinthepiriformcortex,its activationisnotrequiredformaintaininglearning-inducedenhancementofneuronalexcitability. Citation: Liraz O, Rosenblum K, Barkai E (2009) CAMKII Activation Is Not Required for Maintenance of Learning-Induced Enhancement of Neuronal Excitability.PLoSONE4(1):e4289.doi:10.1371/journal.pone.0004289 Editor:PaulA.Bartell,PennsylvaniaStateUniversity,UnitedStatesofAmerica Receive