Can Depression be Diagnosed by Response to Mothers Face A Personalized Attachment-Based Paradigm for Diagnostic fMRI 英文参考文献.docVIP

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Can Depression be Diagnosed by Response to Mothers Face A Personalized Attachment-Based Paradigm for Diagnostic fMRI 英文参考文献.doc

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Can Depression be Diagnosed by Response to Mothers Face A Personalized Attachment-Based Paradigm for Diagnostic fMRI 英文参考文献

CanDepressionbeDiagnosedbyResponsetoMother’s Face?APersonalizedAttachment-BasedParadigmfor DiagnosticfMRI XianZhang1,ZimriS.Yaseen2*,IgorI.Galynker2,JoyHirsch1,ArnoldWinston3 1Department of Radiology, Department of Psychology, Hatch Research Center, Columbia University, Neurological Institute, New York, New York, United States of America,2DepartmentofPsychiatryandBehavioralSciences,BethIsraelMedicalCenter,NewYork,NewYork,UnitedStatesofAmerica,3DepartmentofPsychiatryand BehavioralSciences,AlbertEinsteinSchoolofMedicine,BethIsraelMedicalCenter,NewYork,NewYork,UnitedStatesofAmerica Abstract Objective: Objective measurement of depression remains elusive. Depression has been associated with insecure attachment,andbothhavebeenassociatedwithchangesinbrainreactivityinresponsetoviewingstandardemotionaland neutralfaces.Inthisstudy,wedevelopedamethodtocalculatepredictedscoresfortheBeckDepressionInventoryII(BDI-II) usingpersonalizedstimuli:fMRIimagingofsubjectsviewingpicturesoftheirownmothers. Methods: 28 female subjects ages 18–30 (14 healthy controls and 14 unipolar depressed diagnosed by MINI psychiatric interview)werescoredontheBeckDepressionInventoryII(BDI-II)andtheAdultAttachmentInterview(AAI)coherenceof mind scale of global attachment security. Subjects viewed pictures of Mother (M), Friend (F) and Stranger (S), during functional magnetic resonance imaging (fMRI). Using a principal component regression method (PCR), a predicted Beck DepressionInventoryII(BDI-II)scorewasobtainedfromactivitypatternsintheparacingulategyrus(Brodmannarea32)and comparedtoclinicaldiagnosis andthemeasuredBDI-IIscore.Thesameprocedurewasperformed forAAIcoherence of mindscores. Results: Activity patterns in BA-32 identified depressed subjects. The categorical agreement between the derived BDI-II score(usingthestandardclinicalcut-scoreof14ontheBDI-II)anddepressiondiagnosisbyMINIpsychiatricinterviewwas 89%,withsensitivity85.7%andspecificity92.8%.PredictedandmeasuredBDI-IIscoreshadacorrelati