Can an Infectious Disease Genomics Project Predict and Prevent the Next Pandemic 英文参考文献.docVIP

Perspective CananInfectiousDiseaseGenomicsProjectPredictand PreventtheNextPandemic? RajeshGupta¤*,MarkH.Michalski¤,FrankR.Rijsberman G,MountainView,California,UnitedStatesofAmerica Webelieve thatthereisgreat potential inthesystematicapplicationofgenomics, proteomics, and bioinformatics to infec- tious diseases, and that this potential has yettobefullyrealized.Wesuggestthatthe international community unite under an InfectiousDiseaseGenomicsProject,anal- ogous to the Human Genome Project, with a goal of a comprehensive, open- access system of genomic information to accelerate scientific understanding and product development in the very settings where diseases have the highest probabil- ity of emerging. If properly structured, such an approach could shift fundamen- tally the global response to emerging infectiousdiseases. influenza(commonlyreferredtoas‘‘swine flu’’)[23–26]. N Sequencingandothermoleculartech- nologies are everyday tools-of-the- trade in every district hospital and laboratory in hotspots of emerging infectious disease, such as southeast Asiaandsub-SaharanAfrica. Tofullyharnessthebenefitofgenomics ininfectiousdiseases,achainofoverarch- ing activities must occur. First, under- standingthedynamicsofinfectiousdiseas- es through the genomics lens requires a tremendous amount of integrated com- parative sequence, expression, epigenetic, and proteomic data from a variety of pathogens (bacteria, virus, protozoa, fun- gi),vectors(arthropodandaviansources), reservoirs(non-humanmammals,environ- ment)andhumanhosts.Second,generat- ing, collating, organizing, and curating thesedataisanessentialpublichealthtask. Third,translatingthisinformationtotools to improve surveillance and response mechanismsiscriticaltoeffectivelyimpact diseasemanagement. N N Automated molecular diagnostic as- says are low-cost, reduced at least to thesizeofasmartmobilephone,and can return definitive diagnoses of a range of specialized known pathogen panelsatthepointofcare. Arangeofproduc