Canadian Valuation of EQ-5D Health States Preliminary Value Set and Considerations for Future Valuation Studies 英文参考文献.docVIP

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Canadian Valuation of EQ-5D Health States Preliminary Value Set and Considerations for Future Valuation Studies 英文参考文献.doc

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Canadian Valuation of EQ-5D Health States Preliminary Value Set and Considerations for Future Valuation Studies 英文参考文献

CanadianValuationofEQ-5DHealthStates:Preliminary ValueSetandConsiderationsforFutureValuation Studies NickBansback1,2,3*,AkiTsuchiya3,4,JohnBrazier3,AslamAnis1,2 1SchoolofPopulationandPublicHealth,UniversityofBritishColumbia,Vancouver,BritishColumbia,Canada,2CentreforHealthEvaluationandOutcomeSciences,St Paul’sHospital,Vancouver,BritishColumbia,Canada,3HealthEconomicsandDecisionSciences,SchoolofHealthandRelatedResearch,UniversityofSheffield,Sheffield, UnitedKingdom,4DepartmentofEconomics,UniversityofSheffield,Sheffield,UnitedKingdom Abstract Background:TheEQ-5Disapreferencebasedinstrumentwhichprovidesadescriptionofarespondent’shealthstatus,and an empirically derived value for that health state often from a representative sample of the general population. It is commonly used to derive Quality Adjusted Life Year calculations (QALY) in economic evaluations. However, values for healthstateshavebeenfoundtodifferbetweencountries.Theobjectiveofthisstudywastodevelopasetofvaluesforthe EQ-5DhealthstatesforuseinCanada. Methods: Values for 48 different EQ-5D health states were elicited using the Time Trade Off (TTO) via a web survey in English. A random effect model was fitted tothe data toestimate values for all 243health states of theEQ-5D. Various modelspecificationswereexplored.ComparisonswithEQ-5DvaluesfromtheUKandUSweremade.Sensitivityanalysis exploreddifferenttransformationsofvaluesworsethandead,andexclusioncriteriaofsubjects. Results:Thefinalmodelwasestimatedfromthevaluesof1145subjectswithsocio-demographicsbroadlyrepresentativeof Canadian general population with the exception of Quebec. This yielded a good fit with observed TTO values, with an overallR2of0.403andameanabsoluteerrorof0.044. Conclusion: A preference-weight algorithm for Canadian studies that include the EQ-5D is developed. The primary limitations regarded the representativeness of the final sample, given the language used (English only), the method of recruitment,andthedifficultyinthetask.Insightsintopote