Cell Survival from Chemotherapy Depends on NF-κB Transcriptional Up-Regulation of Coenzyme Q Biosynthesis 英文参考文献.docVIP

下载本文档

3
0
约4.13万字
约 9页
2017-05-11 发布于上海
举报
版权申诉

Cell Survival from Chemotherapy Depends on NF-κB Transcriptional Up-Regulation of Coenzyme Q Biosynthesis 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Cell Survival from Chemotherapy Depends on NF-κB Transcriptional Up-Regulation of Coenzyme Q Biosynthesis 英文参考文献

CellSurvivalfromChemotherapyDependsonNF-kB TranscriptionalUp-RegulationofCoenzymeQ Biosynthesis GloriaBrea-Calvo1,EmilioSiendones1,Jose′ A.Sa′nchez-Alca′zar1,RafaeldeCabo2,Pla′cidoNavas1* 1Centro Andaluz de Biolog?′a del Desarrollo, Universidad Pablo de Olavide-CSIC and Centre for Biomedical Research on Rare Diseases (CIBERER), ISCIII, Sevilla, Spain, 2LaboratoryofExperimentalGerontology,NationalInstituteonAging,NationalInstitutesofHealth,Baltimore,Maryland,UnitedStatesofAmerica Abstract Background:CoenzymeQ(CoQ)isalipophilicantioxidantthatissynthesizedbyamitochondrialcomplexintegratedbyat least ten nuclear encoded COQ gene products. CoQ increases cell survival under different stress conditions, including mitochondrialDNA(mtDNA)depletionandtreatmentwithcancerdrugssuchascamptothecin(CPT).Wehavepreviously demonstratedthatCPTinducesCoQbiosynthesisinmammalcells. Methodology/Principal Findings: CPT activates NF-kB that binds specifically to two kB binding sites present in the 59- flankingregionoftheCOQ7gene.ThisbindingisfunctionalandinducesboththeCOQ7expressionandCoQbiosynthesis. TheinhibitionofNF-kBactivationincreasescelldeathanddecreasesboth,CoQlevelsandCOQ7expressioninducedbyCPT. Inaddition,usingacelllineexpressingverylowofNF-kB,wedemonstratethatCPTwasincapableofenhancingenhance bothCoQbiosynthesisandCOQ7expressioninthesecells. Conclusions/Significance: We demonstrate here, for the first time, that a transcriptional mechanism mediated by NF-kB regulates CoQ biosynthesis. This finding contributes new data for the understanding of the regulation of the CoQ biosynthesispathway. Citation: Brea-Calvo G,SiendonesE,Sa′nchez-Alca′zar JA, deCaboR,NavasP(2009)CellSurvivalfromChemotherapy DependsonNF-kBTranscriptional Up- RegulationofCoenzymeQBiosynthesis.PLoSONE4(4):e5301.doi:10.1371/journal.pone.0005301 Editor:JoseA.L.Calbet,UniversityofLasPalmasdeGranCanaria,Spain ReceivedJanuary16,2009;AcceptedMarch26,2009;PublishedApril23,2009 Thisisanopen-accessarticledistribute