Development and Preliminary Evaluation of a Multivariate Index Assay for Ovarian Cancer 英文参考文献.docVIP

下载本文档

3
0
约5.23万字
约 11页
2017-05-11 发布于上海
举报
版权申诉

Development and Preliminary Evaluation of a Multivariate Index Assay for Ovarian Cancer 英文参考文献.doc

1、本文档共11页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Development and Preliminary Evaluation of a Multivariate Index Assay for Ovarian Cancer 英文参考文献

DevelopmentandPreliminaryEvaluationofa MultivariateIndexAssayforOvarianCancer SurajD.Amonkar.,GregP.Bertenshaw.,Tzong-HaoChen,KatharineJ.Bergstrom,JinghuaZhao, ParthaSeshaiah,PingYip,BrianC.Mansfield* CorrelogicSystems,Inc.,Rockville,Maryland,UnitedStatesofAmerica Abstract Background: Mostwomenwithaclinicalpresentationconsistentwithovariancancerhavebenignconditions.Therefore methodstodistinguishwomenwithovariancancerfromthosewithbenignconditionswouldbebeneficial.Wedescribethe development and preliminary evaluation of a serum-based multivariate assay for ovarian cancer. This hypothesis-driven studyexaminedwhetheraninformativepatterncouldbedetectedinstageIdiseasethatpersiststhroughlaterstages. Methodology/Principal Findings: Sera, collected under uniform protocols from multiple institutions, representing 176 cases and 187 controls from women presenting for surgery were examined using high-throughput, multiplexed immunoassays. All stages and common subtypes of epithelial ovarian cancer, and the most common benign ovarian conditionswererepresented.Apanelof104antigens,44autoimmuneand56infectiousdiseasemarkerswereassayedand informativecombinationsidentified.Usingatrainingsetof91stageIdatasets,representing61individualsamples,andan equivalentnumberofcontrols,an11-analyteprofile,composedofCA-125,CA19-9,EGF-R,C-reactiveprotein,myoglobin, apolipoprotein A1, apolipoprotein CIII, MIP-1a, IL-6, IL-18 and tenascin C was identified and appears informative for all stagesandcommonsubtypesofovariancancer.Usingatestingsetof245samples,approximatelytwicethesizeofthe modelbuildingset,theclassifierhad91.3%sensitivityand88.5%specificity.Whilethesepreliminaryresultsarepromising, furtherrefinementandextensivevalidationoftheclassifierinaclinicaltrialisnecessarytodetermineifthetesthasclinical value. Conclusions/Significance: We describe a blood-based assay using 11 analytes that can distinguish women with ovarian cancer from those with benign conditions. Preliminary evaluation of the classif