Development of a Standardized Screening Rule for Tuberculosis in People Living with HIV in Resource-Constrained Settings Individual Participant Data Meta-analysis of Observational Studies 英文参考文献.docVIP

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Development of a Standardized Screening Rule for Tuberculosis in People Living with HIV in Resource-Constrained Settings Individual Participant Data Meta-analysis of Observational Studies 英文参考文献.doc

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Development of a Standardized Screening Rule for Tuberculosis in People Living with HIV in Resource-Constrained Settings Individual Participant Data Meta-analysis of Observational Studies 英文参考文献

DevelopmentofaStandardizedScreeningRulefor TuberculosisinPeopleLivingwithHIVinResource- ConstrainedSettings:IndividualParticipantDataMeta- analysisofObservationalStudies HaileyesusGetahun1*,WanitchayaKittikraisak2,CharlesM.Heilig3,ElizabethL.Corbett4,HelenAyles4,5, KevinP.Cain3,AlisonD.Grant4,GavinJ.Churchyard6,MichaelKimerling7,SaritaShah8,StephenD. Lawn4,9,RobinWood9,GaryMaartens10,ReubenGranich1,AnandA.Date3,JayK.Varma2,3 1World Health Organization, Geneva, Switzerland, 2Thailand Ministry of Public Health - U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand,3UnitedStatesCentersforDiseaseControlandPrevention,Atlanta,UnitedStatesofAmerica,4DepartmentofClinicalResearch,LondonSchoolofHygiene Tropical Medicine, London, United Kingdom, 5ZAMBART Project, University of Zambia Ridgeway Campus, Lusaka, Zambia, 6Aurum Institute for Health Research, Johannesburg,SouthAfrica, 7BillandMelindaGatesFoundation,Seattle,UnitedStatesofAmerica, 8AlbertEinsteinCollegeofMedicine,NewYork,UnitedStatesof America,9DesmondTutuHIVCenter,UniversityofCapeTown,SouthAfrica,10DepartmentofMedicine,UniversityofCapeTown,SouthAfrica Abstract Background:TheWorldHealthOrganizationrecommendsthescreeningofallpeoplelivingwithHIVfortuberculosis(TB) disease, followed by TB treatment, or isoniazid preventive therapy (IPT) when TB is excluded. However, the difficulty of reliablyexcludingTBdiseasehasseverelylimitedTBscreeningandIPTuptakeinresource-limitedsettings.Weconductedan individualparticipantdatameta-analysisofprimarystudies,aimingtoidentifyasensitiveTBscreeningrule. MethodsandFindings:Weidentified12studiesthathadsystematicallycollectedsputumspecimensregardlessofsignsor symptoms,atleastonemycobacterialculture,clinicalsymptoms,andHIVandTBdiseasestatus.Bivariaterandom-effects meta-analysis and the hierarchical summary relative operating characteristic curves were used to evaluate the screening performanceofallcombinationsofvariablesofinterest.TBdiseasewasdiagnosedin