Development of Mathematical Models for the Analysis of Hepatitis Delta Virus Viral Dynamics 英文参考文献.docVIP

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Development of Mathematical Models for the Analysis of Hepatitis Delta Virus Viral Dynamics 英文参考文献.doc

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Development of Mathematical Models for the Analysis of Hepatitis Delta Virus Viral Dynamics 英文参考文献

DevelopmentofMathematicalModelsfortheAnalysisof HepatitisDeltaVirusViralDynamics BrunoC.deSousa1*,CelsoCunha2 1CentreforMalariaandTropicalDiseases,AssociatedLaboratory,UnitofEpidemiologyandBiostatistics,InstitutodeHigieneeMedicinaTropical-UniversidadeNovade Lisboa,Lisbon,Portugal,2CentreforMalariaandTropicalDiseases,AssociatedLaboratory,MolecularBiologyUnit,InstitutodeHigieneeMedicinaTropical-Universidade NovadeLisboa,Lisbon,Portugal Abstract Background:Mathematicalmodelshaveshowntobeextremelyhelpfulinunderstandingthedynamicsofdifferentvirus diseases,includinghepatitisB.HepatitisDvirus(HDV)isasatellitevirusofthehepatitisBvirus(HBV).Intheliver,production of new HDV virions depends on thepresence of HBV.There aretwo ways in which HDV can occur in an individual: co- infection and super-infection. Co-infection occurs when an individual is simultaneously infected by HBV and HDV, while super-infectionoccursinpersonswithanexistingchronicHBVinfection. Methodology/PrincipalFindings:Inthisworkamathematicalmodelbasedondifferentialequationsisproposedforthe viraldynamicsofthehepatitisDvirus(HDV)acrossdifferentscenarios.Thismodeltakesintoconsiderationtheknowledge ofthebiologyofthevirusanditsinteractionwiththehost.Inthisworkwewillpresenttheresultsofasimulationstudy where two scenarios were considered, co-infection and super-infection, together with different antiviral therapies. Although,ingeneralthepredictedcourseofHDVinfectionissimilartothatobservedforHBV,weobserveafasterincrease inthenumberofHBVinfectedcellsandviralload.Inmosttestedscenarios,thenumberofHDVinfectedcellsandviralload valuesremainbelowcorrespondingpredictedvaluesforHBV. Conclusions/Significance: The simulation study shows that, under the most commonly used and generally accepted therapy approaches for HDV infection, such as lamivudine (LMV) or ribavirine, peggylated alpha-interferon (IFN) or a combination of both, LMV monotherapy and combination therapy of LMV and IFN were predicted to more effectively reduce the