Diabetes Mellitus and Mortality after Acute Coronary Syndrome as a First or Recurrent Cardiovascular Event 英文参考文献.docVIP

下载本文档

3
0
约2.05万字
约 5页
2017-05-11 发布于上海
举报
版权申诉

Diabetes Mellitus and Mortality after Acute Coronary Syndrome as a First or Recurrent Cardiovascular Event 英文参考文献.doc

1、本文档共5页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Diabetes Mellitus and Mortality after Acute Coronary Syndrome as a First or Recurrent Cardiovascular Event 英文参考文献

DiabetesMellitusandMortalityafterAcuteCoronary SyndromeasaFirstorRecurrentCardiovascularEvent RichardM.Cubbon1,AfrozeAbbas1,StephenB.Wheatcroft1,NiamhKilcullen2,RajDas2 ,Christine Morrell2,JulianH.Barth3,MarkT.Kearney1*,AlistairS.Hall2 fortheEMMACE-2investigators 1DivisionofCardiovascularandDiabetesResearch,LeedsInstituteofGenetics,HealthTherapeutics,TheLIGHTLaboratories,TheUniversityofLeeds,Leeds,United Kingdom,2C-NETGroup,ClinicalCardiology,LeedsGeneralInfirmary,Leeds,UnitedKingdom,3DepartmentofClinicalBiochemistryandImmunology,LeedsGeneral Infirmary,Leeds,UnitedKingdom Abstract Background:DiabetesMellitus(DM)isassociatedwithadversecardiovascularprognosis.However,theriskassociatedwith DMmayvarybetweenindividualsaccordingtotheiroverallcardiovascularriskburden.Therefore,weaimedtodetermine whetherDMisassociatedwithpooroutcomeinpatientspresentingwithAcuteCoronarySyndrome(ACS)accordingtothe indexepisodebeingafirstorrecurrentcardiovascularevent. MethodsandFindings:Weconductedaretrospectiveanalysisofaprospectivecohortstudyinvolving2499consecutively admitted patients with confirmed ACS in 11 UK hospitals during 2003. Usual care was provided for all participants. Demographicfactors,co-morbidityandtreatment(duringadmissionandatdischarge)factorswererecorded.Theprimary outcomewasallcausemortality(median2yearfollowup),comparedforcohortswithandwithoutDMaccordingtotheir prior cardiovascular disease (CVD) disease status. Adjusted analyses were performed with Cox proportional hazards regressionanalysis.Withintheentirecohort,DMwasassociatedwithanunadjusted45%increaseinmortality.However,in patients free of a history of CVD, mortality of those with and without DM was similar (18.8% and 19.7% respectively; p=0.74).InthegroupwithCVD,mortalityofpatientswithDMwassignificantlyhigherthanthosewithoutDM(46.7%and 33.2%respectively;p,0.001).TheageandsexadjustedinteractionbetweenDMandCVDinpredictingmortalitywashighly significant(p=0.002)andpersistedafteraccountingforcomorbiditiesandtreat