Diagnostic Accuracy of a Rapid Influenza Test for Pandemic Influenza A H1N1 英文参考文献.docVIP

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Diagnostic Accuracy of a Rapid Influenza Test for Pandemic Influenza A H1N1 英文参考文献.doc

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Diagnostic Accuracy of a Rapid Influenza Test for Pandemic Influenza A H1N1 英文参考文献

DiagnosticAccuracyofaRapidInfluenzaTestfor PandemicInfluenzaAH1N1 AubreeGordon1,2*,ElsaVidea3,SairaSabor?′o4,RogerLo′pez4,GuillerminaKuan5,AngelBalmaseda4, EvaHarris6 1DivisionofEpidemiology,SchoolofPublicHealth,UniversityofCalifornia,Berkeley,California,UnitedStatesofAmerica,2JohnE.FogartyInternationalCenter,National InstitutesofHealth,Bethesda,Maryland,UnitedStatesofAmerica,3SustainableSciencesInstitute,Managua,Nicaragua,4DepartamentodeVirolog?′a,CentroNacionalde Diagno′sticoyReferencia,MinistryofHealth,Managua,Nicaragua,5CentrodeSaludSo′cratesFloresVivas,MinistryofHealth,Managua,Nicaragua,6DivisionofInfectious DiseasesandVaccinology,SchoolofPublicHealth,UniversityofCalifornia,Berkeley,California,UnitedStatesofAmerica Abstract Background:WiththecurrentinfluenzaAH1N1pandemic(H1N1pdm),itisextremelyimportantthatclinicianscanquickly andaccuratelyidentifyinfluenzacases. Methodology/PrincipalFindings:ToinvestigatetheperformanceoftheQuickVueInfluenzaA+Brapidtest,weconducted a prospective study of the diagnostic accuracy of the QuickVue Influenza A+B test compared to real-time reverse transcriptase-polymerasechainreaction(RT-PCR)forinfluenzaAH1N1pdminNicaraguanchildrenaged2to14years.Rapid test sensitivity and specificity compared to real-time RT-PCR were 64.1% (95% CI 53.5, 73.9) and 98.3% (95.0, 99.6), respectively.Agreementbetweenthetwotestswas86.4%(95%CI81.7,90.3),andkappawascalculatedtobe0.67(95%CI 0.56,0.76).Performanceoftherapidtestvariedbydayofpresentation,withasensitivityof41.7%(95%CI22.1,63.4)for samplesfromchildrenpresentingonthedayofsymptomonsetandasensitivityof72.1%(95%CI59.9,82.3)forsamples fromchildrenpresentingoneormoredayspost-symptomonset. Conclusions/Significance: We found that the rapid test performed with moderate sensitivity and high specificity. Test performancevariedbydayofonset,withlowersensitivityonthedayofsymptomonset. Citation:GordonA,VideaE,Sabor?′oS,Lo′pezR,KuanG,etal.(2010)DiagnosticAccuracyofaRapidInfluenzaTestforPandemicInfluenzaAH1N1.PLo