Dietary Glycemic Load and Glycemic Index and Risk of Coronary Heart Disease and Stroke in Dutch Men and Women The EPIC-MORGEN Study 英文参考文献.docVIP
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Dietary Glycemic Load and Glycemic Index and Risk of Coronary Heart Disease and Stroke in Dutch Men and Women The EPIC-MORGEN Study 英文参考文献
DietaryGlycemicLoadandGlycemicIndexandRiskof
CoronaryHeartDiseaseandStrokeinDutchMenand
Women:TheEPIC-MORGENStudy
KoertN.J.Burger1,2,JolineW.J.Beulens2,JolandaM.A.Boer1,AnnemiekeM.W.Spijkerman1,DaphneL.
vanderA1*
1NationalInstituteforPublicHealthandtheEnvironment,Bilthoven,TheNetherlands,2JuliusCenterforHealthSciencesandPrimaryCare,UniversityMedicalCenter
Utrecht,Utrecht,TheNetherlands
Abstract
Background:Theassociationsofglycemicload(GL)andglycemicindex(GI)withtheriskofcardiovasculardiseases(CVD)
arenotwell-established,particularlyinmen,andmaybemodifiedbygender.
Objective:ToassesswhetherhighdietaryGLandGIincreasetheriskofCVDinmenandwomen.
Methods: Alarge prospective cohort study (EPIC-MORGEN) wasconducted within the general Dutch population among
8,855menand10,753women,aged21–64yearsatbaseline(1993–1997)andfreeofdiabetesandCVD.Dietaryintakewas
assessedwithavalidatedfood-frequencyquestionnaireandGIandGLwerecalculatedusingFoster-Powell’sinternational
tableofGI.Informationonmorbidityandmortalitywasobtainedthroughlinkagewithnationalregistries.Coxproportional
hazardsanalysiswasperformedtoestimatehazardratios(HRs)forincidentcoronaryheartdisease(CHD)andstroke,while
adjustingforage,CVDriskfactors,anddietaryfactors.
Results:Duringameanfollow-upof11.9years,581CHDcasesand120strokecasesoccurredamongmen,and300CHD
casesand109strokecasesoccurredamongwomen.Inmen,GLwasassociatedwithanincreasedCHDrisk(adjustedHRper
SDincrease,1.17[95%CI,1.02–1.35]),whilenosignificantassociationwasfoundinwomen(1.09[0.89–1.33]).GIwasnot
associatedwithCHDriskinbothgenders,whileitwasassociatedwithincreasedstrokeriskinmen(1.27[1.02–1.58])butnot
inwomen(0.96[0.75–1.22]).Similarly,totalcarbohydrateintakeandstarchintakewereassociatedwithahigherCHDriskin
men(1.23[1.04–1.46];and1.24[1.07–1.45]),butnotinwomen.
Conclusion:Amongmen,highGLandGI,andhighcarbohydrateandstarchintake,wereassociatedwithincreasedriskof
CVD.
Citation: BurgerKNJ, Beulens JWJ, Boer JMA, Spijkerman AMW, van der A DL (2011) Dietary Glycemi
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