Different Effects of Farrerol on an OVA-Induced Allergic Asthma and LPS-induced Acute Lung Injury 英文参考文献.docVIP

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Different Effects of Farrerol on an OVA-Induced Allergic Asthma and LPS-induced Acute Lung Injury 英文参考文献.doc

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Different Effects of Farrerol on an OVA-Induced Allergic Asthma and LPS-induced Acute Lung Injury 英文参考文献

DifferentEffectsofFarrerolonanOVA-InducedAllergic AsthmaandLPS-inducedAcuteLungInjury XinxinCi.,XiaoChu.,MiaomiaoWei,XiaofengYang,QinrenCai,XumingDeng* InstituteofZoonoses,CollegeofAnimalScienceandVeterinaryMedicine,JilinUniversity,Changchun,Jilin,People’sRepublicofChina Abstract Background:Farrerol,isolatedfromrhododendron,hasbeenshowntohavetheanti-bacterialactivity,butnodetailsonthe anti-inflammatoryactivity.Wefurtherevaluatedtheeffectsofthiscompoundintwoexperimentalmodelsoflungdiseases. Methodology/PrincipalFindings:Fortheasthmamodel,femaleBALB/cmicewerechallengedwithovalbumin(OVA),and thentreateddailywithfarrerol(20and40mg/kg,ip)asatherapeutictreatmentfromday22today26postimmunization. To induce acute lung injury, female BALB/c mice were injected intranasally with LPS and treated with farrerol (20 and 40mg/kg, i.p.) 1h prior to LPS stimulation. Inflammation in the two different models was determined using ELISA, histology, real-time PCR and western blot. Farrerol significantly regulated the phenotype challenged by OVA, like cell number,Th1andTh2cytokineslevelsintheBALF,theOVA-specificIgElevelintheserum,gobletcellhyperplasiainthe airway, airway hyperresponsiveness to inhaled methacholine and mRNA expression of chemokines and their receptors. Furthermore,farrerolmarkedlyattenuatedtheactivationofphosphorylationofAktandnuclearfactor-kB(NF-kB)subunit p65bothinvivoandinvitro.However,farrerolhasnoeffectontheacutelunginjurymodel. Conclusion/Significance:Ourfindingdemonstratesthatthedistinctanti-inflammatoryeffectoffarrerolinthetreatmentof asthmaactsbyinhibitingthePI3KandNF-k Bpathway. Citation:CiX,ChuX,WeiM,YangX,CaiQ,etal.(2012)DifferentEffectsofFarrerolonanOVA-InducedAllergicAsthmaandLPS-inducedAcuteLungInjury.PLoS ONE7(4):e34634.doi:10.1371/journal.pone.0034634 Editor:PadraicG.Fallon,TrinityCollegeDublin,Ireland ReceivedDecember29,2011;AcceptedMarch2,2012;PublishedApril26,2012 Copyright:?2012Cietal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommo