Development of Low-Cost Inverted Microscope to Detect Early Growth of Mycobacterium tuberculosis in MODS Culture 英文参考文献.docVIP

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Development of Low-Cost Inverted Microscope to Detect Early Growth of Mycobacterium tuberculosis in MODS Culture 英文参考文献.doc

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Development of Low-Cost Inverted Microscope to Detect Early Growth of Mycobacterium tuberculosis in MODS Culture 英文参考文献

DevelopmentofLow-CostInvertedMicroscopetoDetect EarlyGrowthofMycobacteriumtuberculosisinMODS Culture MirkoZimic1*,AbnerVelazco2,Germa′nComina2,JorgeCoronel1,PatriciaFuentes1,CarmenG.Luna1, PatriciaSheen1,RobertH.Gilman1,3,4,DavidA.J.Moore1,3,4,5 1UnidaddeBioinforma′tica yLaboratoriodeEnfermedadesInfecciosas,LaboratoriosdeInvestigacio′nyDesarrollo,FacultaddeCienciasyFilosof?′a,UniversidadPeruana CayetanoHeredia,SanMart?′ndePorras,Lima,Peru′,2LaboratoriodePel?′culasDelgadas,Facultad deCiencias,UniversidadNacionaldeIngenier?′a,Rimac,Lima,Peru′, 3Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, 4Department of Infectious DiseasesandImmunity,FacultyofMedicine,WellcomeCentreforClinicalTropicalMedicine,ImperialCollegeLondon,London,UnitedKingdom,5ClinicalResearchUnit, DepartmentofInfectiousandTropicalDiseases,LondonSchoolofHygieneandTropicalMedicine,London,UnitedKingdom Abstract Background: The microscopic observation drug susceptibility (MODS) assay for rapid, low-cost detection of tuberculosis and multidrug resistant tuberculosis depends upon visualization of the characteristic cording colonies of Mycobacterium tuberculosisinliquidmedia.ThishasconventionallyrequiredaninvertedlightmicroscopeinordertoinspecttheMODS culture plates from below. Few tuberculosis laboratories have this item and the capital cost of $5,000 for a high-end microscopecouldbeasignificantobstacletoMODSroll-out. Methodology:Wehypothesizedthattheprecisedefinitionprovidedbycostlyhigh-specificationinvertedlightmicroscopes mightnotbenecessaryforpatternrecognition. Significance:Inthisworkwedescribethedevelopmentofalow-costartesenalinvertedmicroscopethatcanoperatein both a standard or digital mode to effectively replace the expensive commercial inverted light microscope, and an integratedsystemthatcouldpermitalocalandremotediagnosisoftuberculosis. Citation: Zimic M, Velazco A, Comina G, Coronel J, Fuentes P, et al. (2