Different Genes Interact with Particulate Matter and Tobacco Smoke Exposure in Affecting Lung Function Decline in the General Population 英文参考文献.docVIP

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Different Genes Interact with Particulate Matter and Tobacco Smoke Exposure in Affecting Lung Function Decline in the General Population 英文参考文献.doc

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Different Genes Interact with Particulate Matter and Tobacco Smoke Exposure in Affecting Lung Function Decline in the General Population 英文参考文献

DifferentGenesInteractwithParticulateMatterand TobaccoSmokeExposureinAffectingLungFunction DeclineintheGeneralPopulation IvanCurjuric1,2,MedeaImboden1,2,RachelNadif3,4,AshishKumar1,2,5,ChristianSchindler1,2 MargotHaun6,FlorianKronenberg6,NinoKu¨nzli1,2,HarishPhuleria1,2,DirkjeS.Postma7,ErichW.Russi8, ThierryRochat9,FlorenceDemenais10,11,12,NicoleM.Probst-Hensch1,2 , * 1Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute SwissTPH, Basel, Switzerland, 2University of Basel, Basel, Switzerland, 3INSERM,U1018,CESPCentreforresearchinEpidemiologyandPopulationHealth,RespiratoryandEnvironmentalEpidemiologyTeam,Villejuif,France,4Universite′Paris- Sud11,UMRS1018,Villejuif,France,5WellcomeTrustCentreforHumanGenetics,UniversityofOxford,Oxford,UnitedKingdom,6DivisionofGeneticEpidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria, 7Department of Pulmonary Medicine and Tuberculosis,UniversityMedicalCenterGroningen,UniversityofGroningen,Groningen,TheNetherlands,8DivisionofPulmonaryMedicine,UniversityHospitalZu¨rich, Zu¨rich,Switzerland,9DivisionofPulmonaryMedicine,GenevaUniversityHospitals,Geneva,Switzerland,10INSERM,U946,GeneticVariationandHumanDiseasesUnit, Paris, France, 11Fondation Jean Dausset - Centre d’Etude du Polymorphisme Humain (CEPH), Paris, France, 12Universite′ Paris Diderot, Sorbonne Paris Cite′, Institut Universitaired’He′matologie,Paris,France Abstract Background:Oxidativestressrelatedgenesmodifytheeffectsofambientairpollutionortobaccosmokingonlungfunction decline. The impact of interactions might be substantial, but previous studies mostly focused on main effects of single genes. Objectives:Westudiedtheinteractionofbothexposureswithabroadsetofoxidative-stressrelatedcandidategenesand pathwaysonlungfunctiondeclineandcontrastedinteractionsbetweenexposures. Methods: For 12679 single nucleotide polymorphisms (SNPs), change in forced expiratory volume in on