Differential Effects of Two Fermentable Carbohydrates on Central Appetite Regulation and Body Composition 英文参考文献.docVIP

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Differential Effects of Two Fermentable Carbohydrates on Central Appetite Regulation and Body Composition 英文参考文献.doc

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Differential Effects of Two Fermentable Carbohydrates on Central Appetite Regulation and Body Composition 英文参考文献

DifferentialEffectsofTwoFermentableCarbohydrates onCentralAppetiteRegulationandBodyComposition TulikaArora1,5.,RueyLengLoo4,7.,JelenaAnastasovska2.,GlennR.Gibson3,KieranM.Tuohy3,6 ,Raj KumarSharma5,JonathanR.Swann3,EddieR.Deaville3,MicheleL.Sleeth1,E.LouiseThomas2, ElaineHolmes4,JimmyD.Bell2,GaryFrost1* 1NutritionandDieteticResearchGroup,DepartmentofInvestigativeMedicine,ImperialCollegeLondon,HammersmithHospital,London,UnitedKingdom,2Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, United Kingdom, 3Department of Food and NutritionalSciences,UniversityofReading,Reading,UnitedKingdom,4DepartmentofSurgeryCancer,ImperialCollegeLondon,SouthKensingtonCampus,London, UnitedKingdom,5DivisionofAnimalBiochemistry,NationalDairyResearchInstitute,Karnal,Haryana,India,6NutritionandNutrigenomicsGroup,DepartmentofFood QualityandNutrition,ResearchandInnovationCentre,FondazioneEdmundMachdiSanMicheleall’Adige,Trento,Italy,7MedwaySchoolofPharmacy,Universitiesof KentandGreenwich,Kent,UnitedKingdom Abstract Background:Obesityisrisingatanalarmingrateglobally.Differentfermentablecarbohydrateshavebeenshowntoreduce obesity.Theaimofthepresentstudywastoinvestigateiftwodifferentfermentablecarbohydrates(inulinandb-glucan) exertsimilareffectsonbodycompositionandcentralappetiteregulationinhighfatfedmice. Methodology/PrincipalFindings:ThirtysixC57BL/6malemicewererandomizedandmaintainedfor8weeksonahighfat dietcontaining0%(w/w)fermentablecarbohydrate,10%(w/w)inulinor10%(w/w)b-glucanindividually.Fecalandcecal microbialchangesweremeasuredusingfluorescentinsituhybridization,fecalmetabolicprofilingwasobtainedbyproton nuclear magnetic resonance (1H NMR), colonic short chain fatty acids were measured by gas chromatography, body composition and hypothalamic neuronal activation were measured using magnetic resonance imaging (MRI) and manganese enhanced MRI (MEMRI),respectively, PYY (peptide YY) concentration was determinedby radioimm