Diversity of Intrinsic Frequency Encoding Patterns in Rat Cortical Neurons—Mechanisms and Possible Functions 英文参考文献.docVIP

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Diversity of Intrinsic Frequency Encoding Patterns in Rat Cortical Neurons—Mechanisms and Possible Functions 英文参考文献.doc

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Diversity of Intrinsic Frequency Encoding Patterns in Rat Cortical Neurons—Mechanisms and Possible Functions 英文参考文献

DiversityofIntrinsicFrequencyEncodingPatternsinRat CorticalNeurons—MechanismsandPossibleFunctions JingKang2,HughP.C.Robinson3*,JianfengFeng1,2* 1CenterforComputationalSystemsBiology,FudanUniversity,Shanghai,People’sRepublicofChina,2DepartmentofComputerScience,UniversityofWarwick,Coventry, UnitedKingdom,3DepartmentofPhysiology,DevelopmentandNeuroscience,UniversityofCambridge,Cambridge,UnitedKingdom Abstract Extracellularrecordingsofsingleneuronsinprimaryandsecondarysomatosensorycorticesofmonkeysinvivohaveshown that their firing rate can increase, decrease, or remain constant in different cells, as the external stimulus frequency increases.Weobservedsimilarintrinsicfiringpatterns(increasing,decreasingorconstant)inratsomatosensorycortexin vitro,whenstimulatedwithoscillatoryinputusingconductanceinjection(dynamicclamp).Theunderlyingmechanismof thisobservationisnotobvious,andpresentsachallengeformathematicalmodelling.Weproposeasimpleprinciplefor describing this phenomenon using a leaky integrate-and-fire model with sinusoidal input, an intrinsic oscillation and Poissonnoise.Additionalenhancementofthegainofencodingcouldbeachievedbylocalnetworkconnectionsamongst diverseintrinsicresponsepatterns.Ourworkshedslightonthepossiblecellularandnetworkmechanismsunderlyingthese opposingneuronalresponses,whichservetoenhancesignaldetection. Citation: Kang J, Robinson HPC, Feng J (2010) Diversity of Intrinsic Frequency Encoding Patterns in Rat Cortical Neurons—Mechanisms and Possible Functions.PLoSONE5(3):e9608.doi:10.1371/journal.pone.0009608 Editor:LisetMenendezdelaPrida,InstitutoCajal-CSIC,Spain ReceivedAugust25,2009;AcceptedJanuary27,2010;PublishedMarch19,2010 Copyright: ? 2010 Kang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:TheworkwasfundedbytheWarwickPostgraduateResearchFellowship,Institute