Donor Age-Related Biological Properties of Human Dental Pulp Stem Cells Change in Nanostructured Scaffolds 英文参考文献.docVIP

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Donor Age-Related Biological Properties of Human Dental Pulp Stem Cells Change in Nanostructured Scaffolds 英文参考文献.doc

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Donor Age-Related Biological Properties of Human Dental Pulp Stem Cells Change in Nanostructured Scaffolds 英文参考文献

DonorAge-RelatedBiologicalPropertiesofHuman DentalPulpStemCellsChangeinNanostructured Scaffolds EribertoBressan1,2,LetiziaFerroni3,ChiaraGardin3,PaoloPinton2,EdoardoStellini1,DanieleBotticelli4, StefanoSivolella1,2,BarbaraZavan3* 1DepartmentofNeurosciences,UniversityofPadua,Padua,Italy,2DepartmentofExperimentalandDiagnosticMedicine,SectionofGeneralPathology,Interdisciplinary CenterfortheStudyofInflammation(ICSI)andLTTACenter,UniversityofFerrara,Ferrara,Italy,3DepartmentofBiomedicalSciences,UniversityofPadua,Padua,Italy, 4ARDEC,AriminumOdontologica,Rimini,Italy Abstract Theaimofthepresentworkistostudyhowbiologicalproperties,suchasproliferationandcommitmentability,ofhuman adultdentalpulpstemcells (DPSCs)relatetotheageofthedonor.Humandentalpulpswereextractedfrommolars of healthyadultsubjectsaged16to.66years.DPSCswereisolatedandculturedinthepresenceofosteogenic,neurogenic, orvasculogenicdifferentiationmedium.Proliferationabilitywasevaluatedbydeterminingdoublingtime,andcommitment abilitywasevaluatedbygeneexpressionandmorphologicalanalysesfortissue-specificmarkers.Theresultsconfirmawell- definedproliferativeabilityforeachdonoragegroupatanearlyinvitropassage(p2).DPSCsfromyoungerdonors(upto35 years)maintainthisabilityinlong-termcultures(p8).Stemcellsofallagedonorgroupsmaintaintheircommitmentability duringinvitroculture.InvivotestsonthecriticalsizedefectrepairprocessconfirmedthatDPSCsofalldonoragesarea potenttoolforbonetissueregenerationwhenmixedwith3Dnanostructuredscaffolds. Citation:BressanE,FerroniL,GardinC,PintonP,StelliniE,etal.(2012)DonorAge-RelatedBiologicalPropertiesofHumanDentalPulpStemCellsChangein NanostructuredScaffolds.PLoSONE7(11):e49146.doi:10.1371/journal.pone.0049146 Editor:JohnW.Glod,RobertWoodJohnsonMedicalSchool,UnitedStatesofAmerica ReceivedJune27,2012;AcceptedOctober4,2012;PublishedNovember28,2012 Copyright: ? 2012 Bressan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which per