Dopamine in Motor Cortex Is Necessary for Skill Learning and Synaptic Plasticity 英文参考文献.docVIP

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Dopamine in Motor Cortex Is Necessary for Skill Learning and Synaptic Plasticity 英文参考文献.doc

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Dopamine in Motor Cortex Is Necessary for Skill Learning and Synaptic Plasticity 英文参考文献

DopamineinMotorCortexIsNecessaryforSkillLearning andSynapticPlasticity KatiuskaMolina-Luna1,AnaPekanovic1,SebastianRo¨hrich1,BenjaminHertler1,MaximilianSchubring- Giese1,Mengia-SerainaRioult-Pedotti1,2,AndreasR.Luft1,3 * 1ClinicalNeurorehabilitation,DepartmentofNeurology,UniversityofZurich,Zurich,Switzerland,2DepartmentofNeurosciences,BrownUniversity,Providence,Rhode Island,UnitedStatesofAmerica,3DivisionofBrainInjuryOutcomes,DepartmentofNeurology,JohnsHopkinsUniversity,Baltimore,Maryland,UnitedStatesofAmerica Abstract Preliminary evidence indicates that dopamine given by mouth facilitates the learning of motor skills and improves the recoveryofmovementafterstroke.Themechanismofthesephenomenaisunknown.Here,wedescribeamechanismby demonstratinginratthatdopaminergicterminalsandreceptorsinprimarymotorcortex(M1)enablemotorskilllearning and enhance M1 synaptic plasticity. Elimination of dopaminergic terminals in M1 specifically impaired motor skill acquisition,whichwasrestoreduponDAsubstitution.Executionofapreviouslyacquiredskillwasunaffected.Reversible blockade of M1 D1 and D2 receptors temporarily impaired skill acquisition but not execution, and reduced long-term potentiation (LTP) within M1, a form of synaptic plasticity critically involved in skill learning. These findings identify a behavioralandfunctionalroleofdopaminergicsignalinginM1.DAinM1optimizesthelearningofanovelmotorskill. Citation:Molina-LunaK,PekanovicA,Ro¨hrichS,HertlerB,Schubring-GieseM,etal.(2009)DopamineinMotorCortexIsNecessaryforSkillLearningandSynaptic Plasticity.PLoSONE4(9):e7082.doi:10.1371/journal.pone.0007082 Editor:JanLauwereyns,VictoriaUniversityofWellington,NewZealand ReceivedJune1,2009;AcceptedAugust21,2009;PublishedSeptember17,2009 Copyright:?2009Molina-Lunaetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Thisresearchwasfu