Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient 英文参考文献.docVIP

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Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient 英文参考文献.doc

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Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient 英文参考文献

o PL SMEDICINE Donor-DerivedBrainTumorFollowing NeuralStemCellTransplantation inanAtaxiaTelangiectasiaPatient Ninette Amariglio1,2,Abraham Hirshberg3,BerndW.Scheithauer4,Yoram Cohen1,RonLoewenthal5,LubaTrakhtenbrot2, NuritPaz1,Maya Koren-Michowitz2,DaliaWaldman6,Leonor Leider-Trejo7,Amos Toren6,Shlomi Constantini8, Gideon Rechavi1,6* 1CancerResearchCenter,ShebaMedicalCenterandSacklerSchoolofMedicine,TelAvivUniversity,Tel-Aviv,Israel,2InstituteofHematology,ShebaMedicalCenter,Tel Hashomer,Israel,3DepartmentofOralPathology,SchoolofDentalMedicine,TelAvivUniversity,Tel-Aviv,Israel,4DepartmentofLaboratoryMedicineandPathology,Mayo Clinic,Rochester,Minnesota,UnitedStatesofAmerica,5TissueTypingLaboratory,ShebaMedicalCenterandSacklerSchoolofMedicine,TelAvivUniversity,Tel-Aviv,Israel, 6DepartmentofPediatricHemato-Oncology,ShebaMedicalCenterandSacklerSchoolofMedicine,TelAvivUniversity,Tel-Aviv,Israel,7InstituteofPathology,Tel-Aviv MedicalCenter,Tel-Aviv,Israel,8PediatricNeurosurgery,DanaChildren’sHospital,Tel-AvivMedicalCenter,andSacklerSchoolofMedicine,TelAvivUniversity,Tel-Aviv,Israel Funding:Theauthorsreceivedno specificfundingforthisstudy. ABSTRACT CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. Background Neural stem cells are currently being investigated as potential therapies for neuro- degenerativediseases,stroke,andtrauma.However,concernshavebeenraisedoverthesafety of this experimental therapeutic approach, including, for example, whether there is the potentialfortumorstodevelopfromtransplantedstemcells. AcademicEditor:AlainFischer, Ho?pitalNecker-EnfantsMalades, France Citation:AmariglioN,HirshbergA, ScheithauerBW,CohenY, MethodsandFindings LoewenthalR,etal.(2009)Donor- derivedbraintumorfollowingneural stemcelltransplantationinanataxia telangiectasiapatient.PLoSMed 6(2):e1000029.doi:10.1371/journal. pmed.1000029 A boy with ataxia telangiectasia (AT) was treated with intracerebellar and intrathecal injectionofhumanfetalneuralstemcells.