Down-Regulation of miR-92 in Human Plasma Is a Novel Marker for Acute Leukemia Patients 英文参考文献.docVIP

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Down-Regulation of miR-92 in Human Plasma Is a Novel Marker for Acute Leukemia Patients 英文参考文献.doc

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Down-Regulation of miR-92 in Human Plasma Is a Novel Marker for Acute Leukemia Patients 英文参考文献

Down-RegulationofmiR-92inHumanPlasmaIsaNovel MarkerforAcuteLeukemiaPatients MasamiTanaka1,KosukeOikawa1,2¤,MasakatsuTakanashi1,2,MotoshigeKudo1,JunkoOhyashiki3, KazumaOhyashiki4,MasahikoKuroda1* 1Department of Pathology, Tokyo Medical University, Tokyo, Japan, 2Department of Cell Therapy, Tokyo Medical University, Tokyo, Japan, 3Intractable Disease TherapeuticResearchCenter,TokyoMedicalUniversity,Tokyo,Japan,4FirstDepartmentofInternalMedicine,TokyoMedicalUniversity,Tokyo,Japan Abstract Background: MicroRNAs are a family of 19- to 25-nucleotides noncoding small RNAs that primarily function as gene regulators.AberrantmicroRNAexpressionhasbeendescribedforseveralhumanmalignancies,andthisnewclassofsmall regulatoryRNAshas bothoncogenicandtumorsuppressorfunctions. Despitethis knowledge,thereis littleinformation regardingmicroRNAsinplasmaespeciallybecausemicroRNAsinplasma,ifexist,werethoughttobedigestedbyRNase. Recentstudies,however,haverevealedthatmicroRNAsexistandescapedigestioninplasma. Methodology/PrincipalFindings:WeperformedmicroRNAmicroaraytoobtaininsightintomicroRNAderegulationinthe plasma of a leukemia patient. We have revealed that microRNA-638 (miR-638) is stably present in human plasmas, and microRNA-92a(miR-92a)dramaticallydecreasedintheplasmasofacuteleukemiapatients.Especially,theratioofmiR-92a/ miR-638inplasmawasveryusefulfordistinguishingleukemiapatientsfromhealthybody. Conclusions/Significance: TheratioofmiR-92a/miR-638inplasmahasstrongpotentialforclinicalapplicationasanovel biomarkerfordetectionofleukemia. Citation:TanakaM,OikawaK,TakanashiM,KudoM,OhyashikiJ,etal.(2009)Down-RegulationofmiR-92inHumanPlasmaIsaNovelMarkerforAcuteLeukemia Patients.PLoSONE4(5):e5532.doi:10.1371/journal.pone.0005532 Editor:ChrisJones,InstituteofCancerResearch,UnitedKingdom ReceivedJanuary29,2009;AcceptedApril13,2009;PublishedMay14,2009 Copyright: ? 2009 Tanaka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, whi