Drosophila Fatty Acid Transport Protein Regulates Rhodopsin-1 Metabolism and Is Required for Photoreceptor Neuron Survival 英文参考文献.docVIP

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Drosophila Fatty Acid Transport Protein Regulates Rhodopsin-1 Metabolism and Is Required for Photoreceptor Neuron Survival 英文参考文献.doc

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Drosophila Fatty Acid Transport Protein Regulates Rhodopsin-1 Metabolism and Is Required for Photoreceptor Neuron Survival 英文参考文献

DrosophilaFattyAcidTransportProteinRegulates Rhodopsin-1MetabolismandIsRequiredfor PhotoreceptorNeuronSurvival PierreDourlen1*,BenjaminBertin1,GillesChatelain1,MarionRobin1,FrancescoNapoletano1, MichelJ.Roux2,BertrandMollereau1* 1LaboratoryofMolecularBiologyoftheCell,UMR5239CNRS/EcoleNormaleSupe′rieuredeLyon,UMS344BiosciencesLyonGerland,Universite′ deLyon,Lyon,France, 2TranslationalMedicineandNeurogenetics,IGBMC,UMR7104CNRS/Universite′ deStrasbourg/InsermU964,Strasbourg,France Abstract Tightregulationofthevisualresponseisessentialforphotoreceptorfunctionandsurvival.Visualresponsedysregulation oftenleadstophotoreceptorcelldegeneration,butthecausesofsuchcelldeatharenotwellunderstood.Inthisstudy,we investigatedafattyacidtransportprotein(fatp)nullmutationthatcausedadult-onsetandprogressivephotoreceptorcell death. Consistent with fatp having a role in the retina, we showed that fatp is expressed in adult photoreceptors and accessory cells and that its re-expression in photoreceptors rescued photoreceptor viability in fatp mutants. The visual responseinyoungfatp-mutantflieswasabnormalwithelevatedelectroretinogramamplitudesassociatedwithhighlevels ofRhodopsin-1(Rh1).ReducingRh1levelsinrh1mutantsordeprivingfliesofvitaminArescuedphotoreceptorcelldeathin fatpmutantflies.OurresultsindicatethatfatppromotesphotoreceptorsurvivalbyregulatingRh1abundance. Citation:DourlenP,BertinB,ChatelainG,RobinM,NapoletanoF,etal.(2012)DrosophilaFattyAcidTransportProteinRegulatesRhodopsin-1MetabolismandIs RequiredforPhotoreceptorNeuronSurvival.PLoSGenet8(7):e1002833.doi:10.1371/journal.pgen.1002833 Editor:BingweiLu,StanfordUniversitySchoolofMedicine,UnitedStatesofAmerica ReceivedDecember16,2011;AcceptedJune5,2012;PublishedJuly26,2012 Copyright: ? 2012 Dourlen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.