Drosophila microRNAs 263ab Confer Robustness during Development by Protecting Nascent Sense Organs from Apoptosis 英文参考文献.docVIP

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Drosophila microRNAs 263ab Confer Robustness during Development by Protecting Nascent Sense Organs from Apoptosis 英文参考文献.doc

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Drosophila microRNAs 263ab Confer Robustness during Development by Protecting Nascent Sense Organs from Apoptosis 英文参考文献

DrosophilamicroRNAs263a/bConferRobustnessduring DevelopmentbyProtectingNascentSenseOrgansfrom Apoptosis Vale′rieHilgers1,2¤a,NataschaBushati1*¤b,StephenM.Cohen 1,3 ¤c * 1Temasek Life Sciences Laboratory, National University of Singapore, Singapore, 2PhD Programme, European Molecular Biology Laboratory, Heidelberg, Germany, 3DepartmentofBiologicalSciences,NationalUniversityofSingapore,Singapore Abstract miR-263a/baremembersofaconservedfamilyofmicroRNAsthatareexpressedinperipheralsenseorgansacrosstheanimal kingdom.HerewepresentevidencethatmiR-263aandmiR-263bplayaroleinprotectingDrosophilamechanosensorybristles fromapoptosisbydown-regulatingthepro-apoptoticgeneheadinvolutiondefective.BothmicroRNAsareexpressedinthe bristleprogenitors,anddespiteadifferenceintheirseedsequence,theysharethiskeycommontarget.InmiR-263aandmiR- 263bdeletionmutants,lossofbristlesappearstobesporadic,suggestingthattheroleofthemicroRNAsmaybetoensure robustnessofthepatterningprocessbypromotingsurvivalofthesefunctionallyspecifiedcells.Inthecontextoftheretina, thismechanismensuresthattheinterommatidialbristlesareprotectedduringthedevelopmentallyprogrammedwaveofcell deaththatprunesexcesscellsinordertorefinethepatternofthepupalretina. Citation:HilgersV,BushatiN,CohenSM(2010)DrosophilamicroRNAs263a/bConferRobustnessduringDevelopmentbyProtectingNascentSenseOrgansfrom Apoptosis.PLoSBiol8(6):e1000396.doi:10.1371/journal.pbio.1000396 AcademicEditor:MarvWickens,UniversityofWisconsin,UnitedStatesofAmerica ReceivedNovember24,2009;AcceptedMay6,2010;PublishedJune15,2010 Copyright: ? 2010 Hilgers et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbyEMBL,byEU-FP6grant‘‘Sirocco’’LSHG-CT-2006-037900andbytheSingaporeMillenniumFoundationviacorefundingto Temasek Life Sciences Laboratory [.sg/; http://www.embl.de/; /A