Drug Use and Receipt of Highly Active Antiretroviral Therapy among HIV-Infected Persons in Two U.S. Clinic Cohorts 英文参考文献.docVIP

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Drug Use and Receipt of Highly Active Antiretroviral Therapy among HIV-Infected Persons in Two U.S. Clinic Cohorts 英文参考文献.doc

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Drug Use and Receipt of Highly Active Antiretroviral Therapy among HIV-Infected Persons in Two U.S. Clinic Cohorts 英文参考文献

DrugUseandReceiptofHighlyActiveAntiretroviral TherapyamongHIV-InfectedPersonsinTwoU.S.Clinic Cohorts CatherineC.McGowan1*,DavidD.Weinstein2,CharlesP.Samenow2,SamuelE.Stinnette1 ,Gema Barkanic1,PeterF.Rebeiro1,TimothyR.Sterling1,3,RichardD.Moore4,ToddHulgan1,3 1Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 2Department of Psychiatry,VanderbiltUniversitySchoolofMedicine,Nashville,Tennessee,UnitedStatesofAmerica,3CenterforHealthServicesResearch,VanderbiltUniversitySchoolof Medicine, Nashville, Tennessee, United States of America, 4Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United StatesofAmerica Abstract Objective:Druguseandreceiptofhighlyactiveantiretroviraltherapy(HAART)wereassessedinHIV-infectedpersonsfrom theComprehensiveCareCenter(CCC;Nashville,TN)andJohnsHopkinsUniversityHIVClinic(JHU;Baltimore,MD)between 1999and2005. Methods: Participants with and without injection drug use (IDU) history in the CCC and JHU cohorts were evaluated. Additional analysis of persons with history of IDU, non-injection drug use (NIDU), and no drug use from CCC were performed.ActivityofIDUandNIDUalsowasassessedfortheCCCcohort.HAARTuseandtimeonHAARTwereanalyzed accordingtodrugusecategoryandsiteofcare. Results:1745personswereincludedfromCCC:268(15%)withIDUhistoryand796(46%)withNIDUhistory.1977persons wereincludedfromJHU:731(35%)withIDUhistory.Overall,thecohortsdifferedinIDUriskfactorrates,age,race,sex,and time in follow-up. In multivariate analyses, IDU was associated with decreased HAART receipt overall (OR=0.61, 95% CI: [0.45–0.84]andOR=0.58,95%CI:[0.46–0.73],respectivelyforCCCandJHU)andlesstimeonHAARTatJHU(0.70,[0.55– 0.88]),butnotstatisticallyassociatedwithtimeonHAARTatCCC(0.78,[0.56–1.09]).NIDUwasindependentlyassociated withdecreasedHAARTreceipt(0.62,[0.47–0.81])andlesstimeonHAART(0.66,[0.52–0.85])atCCC.Theseassociationswere nota