Dynamic Regulation of H3K27 Trimethylation during Arabidopsis Differentiation 英文参考文献.docVIP

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Dynamic Regulation of H3K27 Trimethylation during Arabidopsis Differentiation 英文参考文献.doc

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Dynamic Regulation of H3K27 Trimethylation during Arabidopsis Differentiation 英文参考文献

DynamicRegulationofH3K27Trimethylationduring ArabidopsisDifferentiation MarcelLafos1,PhillipKroll1,MareikeL.Hohenstatt1,FrazerL.Thorpe2,OliverClarenz1¤ ,Daniel Schubert1* 1InstituteofGenetics,Heinrich-Heine-UniversityDuesseldorf,Duesseldorf,Germany,2InstituteforMolecularPlantSciences,UniversityofEdinburgh,Edinburgh,United Kingdom Abstract Duringgrowthofmulticellularorganisms,identitiesofstemcellsanddifferentiatedcellsneedtobemaintained.Cellfateis epigeneticallycontrolled by theconserved Polycomb-group (Pc-G)proteins that repress theirtargetgenesby catalyzing histoneH3lysine27trimethylation(H3K27me3).AlthoughH3K27me3isassociatedwithmitoticallystablegenerepression, a large fraction of H3K27me3 target genes are tissue-specifically activated during differentiation processes. However, in plantsitiscurrentlyunclearwhetherH3K27me3isalreadypresentinundifferentiatedcellsanddynamicallyregulatedto permittissue-specificgenerepressionoractivation.Weusedwhole-genometilingarraystoidentifytheH3K27me3target genesinundifferentiatedcellsoftheshootapicalmeristemandindifferentiatedleafcells.Hundredsofgenesgainorlose H3K27me3upondifferentiation,demonstratingdynamicregulationofanepigeneticmodificationinplants.H3K27me3is correlated with gene repression, and its release preferentially results in tissue-specific gene activation, both during differentiation and in Pc-G mutants. We further reveal meristem- and leaf-specific targeting of individual gene families includingknownbutalsolikelynovelregulatorsofdifferentiationandstemcellregulation.Interestingly,H3K27me3directly repressesonlyspecifictranscriptionfactorfamilies,butindirectlyactivatesothersthroughH3K27me3-mediatedsilencingof microRNA genes. Furthermore, H3K27me3 targeting of genes involved in biosynthesis, transport, perception, and signal transductionofthephytohormoneauxindemonstratescontrolofanentiresignalingpathway.Basedontheseandprevious analyses, we propose that H3K27me3 is one of the major determinants of tissue-specific express