Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine 英文参考文献.docVIP

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Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine 英文参考文献.doc

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Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine 英文参考文献

DynamicsofParasiteClearanceinCutaneous LeishmaniasisPatientsTreatedwithMiltefosine ThomasP.C.Dorlo1,2*,PieterP.A.M.vanThiel1,GerardJ.Schoone3,YmkjeStienstra1¤,Miche`levan Vugt1,JosH.Beijnen2,PeterJ.deVries1 1Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, 2Department of Pharmacy and Pharmacology, SlotervaartHospital/TheNetherlandsCancerInstitute,Amsterdam,TheNetherlands,3ParasitologyUnit,KITBiomedicalResearch,RoyalTropicalInstitute,Amsterdam,The Netherlands Abstract Parasiteloadswerequantifiedinrepeatedskinbiopsiesfromlesionsof2patientswithOld-Worldcutaneousleishmaniasis (CL)causedbyLeishmaniamajorandL.infantumduringandaftertreatmentwithmiltefosine.Miltefosineinducedarapid therapeuticeffectonbothinfectionswithaninitialdeclineofparasitesof,1log/weekfortheL.majorinfection.These observations illustrate the usability of quantifying parasite loads in skin lesions as a pharmacodynamic measure and quantitativedescriptorofdrugeffectforCLsupportingclinicalassessment. Citation: Dorlo TPC, van Thiel PPAM, SchooneGJ, Stienstra Y, van Vugt M, et al. (2011) Dynamics ofParasite Clearancein CutaneousLeishmaniasis Patients TreatedwithMiltefosine.PLoSNeglTropDis5(12):e1436.doi:10.1371/journal.pntd.0001436 Editor:HechmiLouzir,InstitutPasteurdeTunis,Tunisia ReceivedMay18,2011;AcceptedNovember4,2011;PublishedDecember13,2011 Copyright: ? 2011 Dorlo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Thefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:t.p.dorlo@amc.nl ¤Currentaddress:DivisionofInfectiousDiseases,UniversityMedicalCenterGroningen,UniversityofGroningen,Groningen,TheNetherlands Introduction Academic