Dynamics of Th17 Cells and Their Role in Schistosoma japonicum Infection in C57BL6 Mice 英文参考文献.docVIP

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Dynamics of Th17 Cells and Their Role in Schistosoma japonicum Infection in C57BL6 Mice 英文参考文献.doc

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Dynamics of Th17 Cells and Their Role in Schistosoma japonicum Infection in C57BL6 Mice 英文参考文献

DynamicsofTh17CellsandTheirRoleinSchistosoma japonicumInfectioninC57BL/6Mice XiaoyunWen1.,LeiHe1.,YingChi1,ShaZhou1,JasonHoellwarth2,CuiZhang1,JifengZhu1,CalvinWu2, ShawnDhesi2,XuefengWang1,FengLiu1,ChuanSu1* 1DepartmentofPathogenBiologyandImmunology,DepartmentofPharmacology,JiangsuKeyLaboratoryofPathogenBiology,NanjingMedicalUniversity,Nanjing, People’s Republic of China, 2Department of Educational Affairs, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America Abstract Background:Thecurrentknowledgeofimmunologicalresponsestoschistosomiasis,amajortropicalhelminthicdisease,is insufficient, and a better understanding of these responses would support vaccine development or therapies to control + granuloma-associatedimmunopathology.CD4 Tcellsplaycriticalrolesinbothhostimmuneresponsesagainstparasitic infectionandimmunopathologyinschistosomiasis.TheinductionofThelper(Th)1,Th2andTregulatory(Treg)cellsand theirrolesinschistosomeinfectionsarewell-illustrated.However,littleinvivodataareavailableonthedynamicsofTh17 cells,anotherimportantCD4 Tcellsubset,afterSchistosomajaponicuminfectionorwhetherthesecellsandtheirdefining IL-17cytokinemediatehostprotectiveresponsesearlyininfection. + Methodology: Levels of Th17 and the other three CD4+ T cell subpopulations and the cytokines related to induction or repressionofTh17cellgenerationindifferentstagesofS.japonicuminfectionwereobserved.Contrarytoreportedinvitro studies, our results showed that the Th17 cells were induced along with the Th1, Th2, Treg cells and the IFN-c and IL-4 cytokines in S. japonicum infected mice. The results also suggested that S. japonicum egg antigens but not adult worm antigenspreferentiallyinducedTh17cellgeneration.Furthermore,decreasingIL-17withaneutralizinganti-IL-17monoclonal antibody(mAb)increasedschistosome-specificantibodylevelsandpartialprotectionagainstS.japonicuminfectioninmice. Conclusions:OurstudyisthefirsttoreportthedynamicsofTh17cellsdu