Effect of Dicycloplatin, a Novel Platinum Chemotherapeutical Drug, on Inhibiting Cell Growth and Inducing Cell Apoptosis 英文参考文献.docVIP

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Effect of Dicycloplatin, a Novel Platinum Chemotherapeutical Drug, on Inhibiting Cell Growth and Inducing Cell Apoptosis 英文参考文献.doc

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Effect of Dicycloplatin, a Novel Platinum Chemotherapeutical Drug, on Inhibiting Cell Growth and Inducing Cell Apoptosis 英文参考文献

EffectofDicycloplatin,aNovelPlatinum ChemotherapeuticalDrug,onInhibitingCellGrowthand InducingCellApoptosis Guang-quanLi1,2,Xing-guiChen1,Xing-pingWu2,Jing-dunXie2,Yong-juLiang2,Xiao-qinZhao2 ,Wei- qiangChen1*,Li-wuFu2* 1DepartmentofGeneralSurgery,ChenXingHaiHosital,GuangdongMedicalCollege,Zhongshan,People’sRepublicofChina, 2StateKeyLaboratoryofOncologyin SouthernChina,CancerCenter,SunYat-SenUniversity,Guangzhou,People’sRepublicofChina Abstract Dicycloplatin, a new supramolecular platinum-based antitumor drug, has been approved by the State Food and Administration (SFDA) of China. In this study, we investigated the anticancer activity of dicycloplatin in cancer cells and signalingpathwaysinvolvedindicycloplatin-inducedapoptosis.Dicycloplatininhibitedtheproliferationofcancercellsand increasedthepercentageofapoptosisinaconcentration-dependentmanner.Besides,someapoptosisrelatedeventswere observedaftertreatmentwithdicycloplatin,includingincreaseofreactiveoxygenspecies(ROS),collapseofmitochondrial membranepotential(Dym),releaseofcytochromecfromthemitochondriatothecytosol,upregulationofp53,whichwere accompanied by activation of caspase-9, caspase-3, caspase-8, and poly (ADP-ribose) polymerase cleavage in a concentration-dependent manner. The role of apoptosis in dicycloplatin-mediated cell death was further confirmed by the concomitant treatment with caspase-8 or caspase-9 inhibitors, which inhibited apoptosis and PARP cleavage. Intracellularglutathione(GSH)wasalsofoundtoinhibitthecytotoxiceffectofdicycloplatin.Inconclusion,thesefindings suggest that dicycloplatin induces apoptosis through ROS stress-mediated death receptor pathway and mitochondrial pathwaywhichissimilartocarboplatin. Citation:LiG-q,ChenX-g,WuX-p,XieJ-d,LiangY-j,etal.(2012)EffectofDicycloplatin,aNovelPlatinumChemotherapeuticalDrug,onInhibitingCellGrowth andInducingCellApoptosis.PLoSONE7(11):e48994.doi:10.1371/journal.pone.0048994 Editor:GuillermoVelasco,ComplutenseUniversity,Spain ReceivedApri