Effect of Folic Acid Supplementation on Cardiovascular Outcomes A Systematic Review and Meta-Analysis 英文参考文献.docVIP

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Effect of Folic Acid Supplementation on Cardiovascular Outcomes A Systematic Review and Meta-Analysis 英文参考文献.doc

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Effect of Folic Acid Supplementation on Cardiovascular Outcomes A Systematic Review and Meta-Analysis 英文参考文献

EffectofFolicAcidSupplementationonCardiovascular Outcomes:ASystematicReviewandMeta-Analysis Yu-HaoZhou1.,Jian-YuanTang2.,Mei-JingWu1.,JianLu1.,XinWei3,Ying-YiQin1,ChaoWang1, Jin-FangXu1,JiaHe1* 1Department of Health Statistics, Second Military Medical University, Shanghai, China, 2Office of Compliance and Development, Center for Drug Evaluation, SFDA, Beijing,China,3ShanghaiJiaoTongUniversitySchoolofMedicine,Shanghai,China Abstract Background:Folicacidiswidelyusedtolowerhomocysteineconcentrationsandpreventadversecardiovascularoutcomes. However,theeffectoffolicacidoncardiovasculareventsisnotclearatthepresenttime.Wecarriedoutacomprehensive systematicreviewandmeta-analysistoassesstheeffectsoffolicacidsupplementationoncardiovascularoutcomes. Methodology and Principal Findings: We systematically searched Medline, EmBase, the Cochrane Central Register of Controlled Trials, reference lists of articles, and proceedings of major meetings for relevant literature. We included randomized placebo-controlled trials that reported on the effects of folic acid on cardiovascular events compared to placebo.Of1594identifiedstudies,weincluded16trialsreportingdataon44841patients.Thesestudiesreported8238 major cardiovascular events, 2001 strokes, 2917 myocardial infarctions, and 6314 deaths. Folic acid supplementation as compared to placebo had no effect on major cardiovascular events (RR, 0.98; 95% CI, 0.93–1.04), stroke (RR, 0.89; 95% CI,0.78–1.01), myocardial infarction (RR, 1.00; 95% CI, 0.93–1.07), or deaths from any cause (RR, 1.00;95% CI, 0.96–1.05). Moreover, folic acid as compared to placebo also had no effect on the following secondary outcomes: risk of revascularization(RR,1.05;95%CI,0.95–1.16),acutecoronarysyndrome(RR,1.06;95%CI,0.97–1.15),cancer(RR,1.08;95%CI, 0.98–1.21),vasculardeath(RR,0.94;95%CI,0.88–1.02),ornon-vasculardeath(RR,1.06;95%CI,0.97–1.15). Conclusion/Significance: Folic acid supplementation does not effect on the incidence of major cardiovascular events, str