Effects of Changes in Adiposity and Physical Activity on Preadolescent Insulin Resistance The Australian LOOK Longitudinal Study 英文参考文献.docVIP

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Effects of Changes in Adiposity and Physical Activity on Preadolescent Insulin Resistance The Australian LOOK Longitudinal Study 英文参考文献.doc

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Effects of Changes in Adiposity and Physical Activity on Preadolescent Insulin Resistance The Australian LOOK Longitudinal Study 英文参考文献

EffectsofChangesinAdiposityandPhysicalActivityon PreadolescentInsulinResistance:TheAustralianLOOK LongitudinalStudy RichardD.Telford1,2*,RossB.Cunningham3,RohanM.Telford4,JenniferKerrigan5,PeterE.Hickman1,5, JuliaM.Potter1,5,WalterP.Abhayaratna1,2 1CollegeofMedicine,BiologyandEnvironment,AustralianNationalUniversity,Canberra,Australia,2ClinicalTrialsUnit,CanberraHospital,Canberra,Australia,3Fenner SchoolofEnvironmentandSociety,AustralianNationalUniversity,Canberra,Australia,4CentreforResearchandActioninPublicHealth,FacultyofHealth,Universityof Canberra,Canberra,Australia,5ACTPathology,CanberraHospital,Canberra,Australia Abstract Background:Inapreviouslongitudinalanalysisofourcohortas8to10year-olds,insulinresistance(IR)increasedwithage, butwasnotmodifiedbychangesinpercentbodyfat(%BF),andwasonlyresponsivetochangesinphysicalactivity(PA)in boys.Weaimedtodeterminewhethertheseresponsespersistedasthechildrenapproachedadolescence. Methods:Inthisprospectivecohortstudy,256boysand278girlswereassessedatages8,10and12yearsforfastingblood glucoseandinsulin,%BF(dualenergyX-rayabsorptiometry);PA(7-daypedometers),fitness(multistagerun);andpubertal development(Tannerstage). Results:Fromage8to12years,themedianhomeostaticmodelofIR(HOMA-IR)doubledinboysandincreased250%in girls. By age 12, 23% of boys and 31% of girls had elevated IR, as indicated by HOMA-IR greater than 3. Longitudinal relationships, with important adjustments for covariates body weight, PA, %BF, Tanner score and socioeconomic status showedthat,onaverage,forevery1unitreductionof%BF,HOMA-IRwasloweredby2.2%(95%CI0.04–4)ingirlsand1.6% (95% CI 0–3.2) in boys. Furthermore, in boys but not girls, HOMA-IR was decreased by 3.5% (95%CI 0.5–6.5) if PA was increasedby2100steps/day. Conclusion:Evidencethataquarterofourapparentlyhealthy12year-oldAustralianspossessedelevatedIRsuggeststhat community-basededucationandpreventionstrategiesmaybewarranted.ResponsivenessofIRtochangesin%BFinboth sexesduringlatepreadolescenceandtochangesinPA