Effect of Rhythmic Auditory Stimulation on Gait in Parkinsonian Patients with and without Freezing of Gait 英文参考文献.docVIP

EffectofRhythmicAuditoryStimulationonGaitin ParkinsonianPatientswithandwithoutFreezingofGait PabloArias,JavierCudeiro* NeuroscienceandMotorControlGroup(NEUROcom),DepartmentofMedicine-INEF,UniversityofACorun?a,ACorun?a,Spain Abstract Freezingofgait(FOG)inParkinson’s disease(PD)risesinprevalencewhentheeffectofmedications decays.Itisknown that auditory rhythmic stimulation improves gait in patients without FOG (PD-FOG), but its putative effect on patients withFOG(PD+FOG)attheendofdosehasnotbeenevaluated yet.Thisworkevaluates theeffectofauditory rhythmic stimulationonPD+FOGattheendofdose.10PD+FOGand9PD-FOGpatientsbothattheendofdoseperiods,and10 healthy controls were asked to perform several walking tasks. Tasks were performed in the presence and absence of auditory sensory stimulation. All PD+FOG suffered FOG during the task. The presence of auditory rhythmic stimulation (10% above preferred walking cadence) led PD+FOG to significantly reduce FOG. Velocity and cadence were increased, andturntimereducedinallgroups.Weconcludethatauditorystimulationatthefrequencyproposedmaybeusefulto avoid freezing episodes in PD+FOG. Citation:AriasP,CudeiroJ(2010)EffectofRhythmicAuditoryStimulationonGaitinParkinsonianPatientswithandwithoutFreezingofGait.PLoSONE5(3): e9675.doi:10.1371/journal.pone.0009675 Editor:KatrinaGwinn,BaylorCollegeofMedicine,UnitedStatesofAmerica ReceivedNovember23,2009;AcceptedFebruary17,2010;PublishedMarch22,2010 Copyright: ? 2010 Arias, Cudeiro. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:WorkwassupportedbyXuntadeGalicia(ConselleriadeEducacio′n-2007/000140-0andDireccio′nXeraldeI+D+i;PGIDIT06PXIC137004PN),Spain.The fundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnoc