Facilitation of Male Sexual Behavior in Syrian Hamsters by the Combined Action of Dihydrotestosterone and Testosterone 英文参考文献.docVIP

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Facilitation of Male Sexual Behavior in Syrian Hamsters by the Combined Action of Dihydrotestosterone and Testosterone 英文参考文献.doc

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Facilitation of Male Sexual Behavior in Syrian Hamsters by the Combined Action of Dihydrotestosterone and Testosterone 英文参考文献

FacilitationofMaleSexualBehaviorinSyrianHamsters bytheCombinedActionofDihydrotestosteroneand Testosterone DavidJ.Piekarski1*,NedJ.Place3,IrvingZucker1,2 1DepartmentofPsychology,UniversityofCalifornia,Berkeley,California,UnitedStatesofAmerica,2DepartmentofIntegrativeBiology,UniversityofCalifornia,Berkeley, California,UnitedStatesofAmerica,3DepartmentofPopulationMedicineDiagnosticSciences,CollegeofVeterinaryMedicine,CornellUniversity,Ithaca,NewYork, UnitedStatesofAmerica Abstract Background:Testosterone(T)controlsmaleSyrianhamstersexualbehavior,however,neitherofT’sprimarymetabolites, dihydrotestosterone (DHT) and estradiol (E2), even in highly supraphysiological doses, fully restores sexual behavior in castratedhamsters.DHTandTapparentlyinteractwithandrogenreceptorsdifferentiallytocontrolmalesexualbehavior (MSB), but whether these two hormones act synergistically or antagonistically to control MSB has received scant experimentalattentionandisaddressedinthepresentstudy. Methodology/Principal Findings: Sexually experienced male Syrian hamsters were gonadectomized and monitored 5 weekslatertoconfirmeliminationoftheejaculatoryreflex(week0),atwhichtimetheyreceivedsubcutaneousDHT-filledor emptycapsulesthatremainedinsituforthedurationoftheexperiment.Dailyinjectionsofaphysiologicaldoseof25m gT orvehiclecommencedtwoweeksaftercapsuleimplantation.MSBwastested2,4and5weeksafterTtreatmentbegan. DHTcapsuleswerenomoreeffectivethancontroltreatmentforlong-termrestorationofejaculation.CombinedDHT+T treatment,however,restoredtheejaculatoryreflexmoreeffectivelythanTalone,asevidencedbymorerapidrecoveryof ejaculatorybehavior,shorterejaculationlatencies,andagreaternumberofejaculationsin30minutetests. Conclusions/Significance:DHTandTadministeredtogetherrestoredsexualbehaviortopre-castrationlevelsmorerapidly thandidTalone,whereasDHTandvehiclewerelargelyineffective.TheadditiveactionsofDHTandTonMSBarediscussed inrelationtodifferenteffectsoftheseandrogensonandrogenreceptorsinthemalehamsterbrain