Female Scent Signals Enhance the Resistance of Male Mice to Influenza 英文参考文献.docVIP

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Female Scent Signals Enhance the Resistance of Male Mice to Influenza 英文参考文献.doc

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Female Scent Signals Enhance the Resistance of Male Mice to Influenza 英文参考文献

FemaleScentSignalsEnhancetheResistanceofMale MicetoInfluenza EkaterinaA.Litvinova1,ElenaP.Goncharova2,AllaM.Zaydman3,MarinaA.Zenkova2,MikhailP. Moshkin1,4 * 1LaboratoryofPhysiologicalAdaptationofAnimals,InstituteofSystematicsandEcologyofAnimals,SiberianBranch,RussianAcademyofSciences,Novosibirsk,Russia, 2LaboratoryofNucleicAcidsBiochemistry,InstituteofChemicalBiologyandFundamentalMedicine,SiberianBranch,RussianAcademyofSciences,Novosibirsk,Russia, 3Department ofHistology,NovosibirskInstitute ofTraumatology,Novosibirsk,Russia,4DepartmentofAnimal GeneticResources,Institute ofCytologyandGenetics, SiberianBranch,RussianAcademyofSciences,Novosibirsk,Russia Abstract Background:Thescentfromreceptivefemalemicefunctionsasasignal,whichstimulatesmalemicetosearchforpotential matingpartners.Thissearchingbehavioriscoupledwithinfectionriskduetosniffingbothscentmarksaswellasnasaland anogenitalareasoffemales,whichharborbacteriaandviruses.Considerationofhostevolutionunderunavoidableparasitic pressures, including helminthes, bacteria, viruses, etc., predicts adaptations that help protect hosts against the parasites associatedwithmating. Methods and Findings: We propose that the perception of female signals by BALB/c male mice leads to adaptive redistribution of the immune defense directed to protection against respiratory infection risks. Our results demonstrate migrationofmacrophagesandneutrophilstotheupperairwaysuponexposuretofemaleodorstimuli,whichresultsinan increasedresistanceofthemalestoexperimentalinfluenzavirusinfection.Thismoderateleukocyteinterventionhadno negativeeffectontheaerobicperformanceinmalemice. Conclusions: Our data provide the first demonstration of the adaptive immunological response to female odor stimuli throughinductionofnonspecificimmuneresponsesintheupperrespiratorytract. Citation: Litvinova EA, Goncharova EP, Zaydman AM, Zenkova MA, Moshkin MP (2010) Female Scent Signals Enhance the Resistance of Male Mice to Influenza.PLoSONE5(3):e9473.doi:10.1371/j