Female Mice are Protected against High-Fat Diet Induced Metabolic Syndrome and Increase the Regulatory T Cell Population in Adipose Tissue 英文参考文献.docVIP

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Female Mice are Protected against High-Fat Diet Induced Metabolic Syndrome and Increase the Regulatory T Cell Population in Adipose Tissue 英文参考文献.doc

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Female Mice are Protected against High-Fat Diet Induced Metabolic Syndrome and Increase the Regulatory T Cell Population in Adipose Tissue 英文参考文献

FemaleMiceareProtectedagainstHigh-FatDietInduced MetabolicSyndromeandIncreasetheRegulatoryTCell PopulationinAdiposeTissue UlrikaS.Pettersson1,TomasB.Walde′n1,Per-OlaCarlsson1,2,LeifJansson1,MiaPhillipson1* 1DepartmentofMedicalCellBiology,UppsalaUniversity,Uppsala,Sweden,2DepartmentofMedicalSciences,UppsalaUniversity,Uppsala,Sweden Abstract Sexdifferencesinobesity-inducedcomplicationssuchastype2diabeteshavebeenreported.Theaimofthestudywasto pinpointthemechanismsresultingindifferentoutcomeoffemaleandmalemiceonahigh-fatdiet(HFD).Micefedcontrol or HFD were monitored for weight, blood glucose, and insulin for 14 weeks. Circulating chemokines, islet endocrine functionandbloodflow,aswellasadiposetissuepopulationsofmacrophagesandregulatoryT-lymphocytes(Treg )were thereafterassessed.Despitesimilarweight(43.861.0and40.261.5g,respectively),malebutnotfemalemicedeveloped hyperinsulinemia on HFD as previously described (2.560.7 and 0.560.1pmol/l, respectively) consistent with glucose intolerance.Malemicealsoexhibitedhypertrophicisletswithintactfunctionintermsofinsulinreleaseandbloodperfusion. Low-grade, systemic inflammation was absent in obese female but present in obese male mice (IL-6 and mKC, males: 77.4617 and females: 14.664.9 and 240622pg/ml), and the population of inflammatory macrophages was increasedinintra-abdominaladiposetissuesofhigh-fat-fedmalebutnotfemalemice.Incontrast,theanti-inflammatory Tregcellpopulationincreasedintheadiposetissueoffemalemiceinresponsetoweightgain,whilethenumberdecreased in high-fat-fed male mice. In conclusion, female mice are protected against HFD-induced metabolic changes while maintainingananti-inflammatoryenvironmentintheintra-abdominaladiposetissuewithexpandedTreg cellpopulation, whereas HFD-fed male mice develop adipose tissue inflammation, glucose intolerance, hyperinsulinemia, and islet hypertrophy. Citation:PetterssonUS,Walde′n TB,CarlssonP-O,JanssonL,PhillipsonM(2012)FemaleMiceareProtectedagainstHigh-FatDietInduce