Filariasis Attenuates Anemia and Proinflammatory Responses Associated with Clinical Malaria A Matched Prospective Study in Children and Young Adults 英文参考文献.docVIP

FilariasisAttenuatesAnemiaandProinflammatory ResponsesAssociatedwithClinicalMalaria:AMatched ProspectiveStudyinChildrenandYoungAdults HousseiniDolo1,YayaI.Coulibaly1,BenoitDembele1,SiakaKonate1,SiakaY.Coulibaly1, SalifS.Doumbia1,AbdallahA.Diallo1,LamineSoumaoro1,MichelE.Coulibaly1,SeidinaA.S.Diakite1, AldioumaGuindo1,MichaelP.Fay2,SimonMetenou3,ThomasB.Nutman3,AmyD.Klion3* 1FacultyofMedicine,PharmacyandDentistry,UniversityofBamako,Bamako,Mali,2BiostatisticsResearchBranch,NationalInstituteofAllergyandInfectiousDiseases, National Institutes of Health, Bethesda, Maryland, United States of America, 3Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesofAmerica Abstract Background:Wuchereriabancrofti(Wb)andMansonellaperstans(Mp)areblood-bornefilarialparasitesthatareendemicin many countries of Africa, including Mali. The geographic distribution of Wb and Mp overlaps considerably with that of malaria, and coinfection is common. Although chronic filarial infection has been shown to alter immune responses to malariaparasites,itseffectonclinicalandimmunologicresponsesinacutemalariaisunknown. Methodology/PrincipalFindings:Toaddressthisquestion,31filaria-positive(FIL+)and31filaria-negative(FIL2 )children and young adults, matched for age, gender and hemoglobin type, were followed prospectively through a malaria transmission season. Filarial infection was defined by the presence of Wb or Mp microfilariae on calibrated thick smears performedbetween10pmand2amand/orbythepresenceofcirculatingfilarialantigeninserum.Clinicalmalariawas definedasaxillarytemperature$37.5uCoranothersymptomorsigncompatiblewithmalariainfectionplusthepresenceof asexualmalariaparasitesonathickbloodsmear.Althoughtheincidenceofclinicalmalaria,timetofirstepisode,clinical signs and symptoms, and malaria parasitemia were comparable between the two groups, geometric mean hemoglobin levels were significantly decreased in