Focus–Specific Clinical Profiles in Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense 英文参考文献.docVIP

下载本文档

2
0
约6.07万字
约 12页
2017-05-11 发布于上海
举报
版权申诉

Focus–Specific Clinical Profiles in Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense 英文参考文献.doc

1、本文档共12页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Focus–Specific Clinical Profiles in Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense 英文参考文献

Focus–SpecificClinicalProfilesinHumanAfrican TrypanosomiasisCausedbyTrypanosomabrucei rhodesiense LornaM.MacLean1*,MartinOdiit2,JohnE.Chisi3,PeterG.E.Kennedy4,JeremyM.Sternberg5 1DepartmentofBiology,HullYorkMedicalSchool,CentreforImmunologyandInfection,UniversityofYork,York,UnitedKingdom,2UgandaAIDSCommission,Kampala, Uganda,3CollegeofMedicine,UniversityofMalawi,Blantyre,Malawi,4DepartmentofNeurology,UniversityofGlasgow,SouthernGeneralHospital,Glasgow,United Kingdom,5InstituteofBiologicalandEnvironmentalSciences,UniversityofAberdeen,Aberdeen,UnitedKingdom Abstract Background: Diverse clinical features have been reported in human African trypanosomiasis (HAT) foci caused by Trypanosomabruceirhodesiense(T.b.rhodesiense)givingrisetothehypothesisthatHATmanifestsasachronicdiseasein South-EastAfricancountriesandincreasedinvirulencetowardstheNorth.Suchvariationindiseaseseveritysuggeststhere are differences in host susceptibility to trypanosome infection and/or genetic variation in trypanosome virulence. Our moleculartoolsallowustostudytheroleofhostandparasitegenotypes,butobtainingmatchedextensiveclinicaldata fromalargecohortofHATpatientshaspreviouslyprovedproblematic. Methods/Principal Findings: We present a retrospective cohort study providing detailed clinical profiles of 275 HAT patientsrecruitedintwonorthernfoci(Uganda)andonesouthernfocus(Malawi)inEastAfrica.Characteristicclinicalsigns and symptoms of T.b.rhodesiense infection were recorded and the degree of neurological dysfunction determined on admission. Clinical observations were mapped by patient estimated post-infection time. We have identified common presenting symptoms in T.b.rhodesiense infection; however, marked differences in disease progression and severity were identifiedbetweenfoci.HATwascharacterisedasachronichaemo-lymphaticstageinfectioninMalawi,andasanacute diseasewithmarkedneurologicalimpairmentinUganda.WithinUganda,amorerapidprogressiontomeningo-encephaltic stage of infection was observed in one fo