Folic Acid Transport to the Human Fetus Is Decreased in Pregnancies with Chronic Alcohol Exposure 英文参考文献.docVIP

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Folic Acid Transport to the Human Fetus Is Decreased in Pregnancies with Chronic Alcohol Exposure 英文参考文献.doc

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Folic Acid Transport to the Human Fetus Is Decreased in Pregnancies with Chronic Alcohol Exposure 英文参考文献

FolicAcidTransporttotheHumanFetusIsDecreasedin PregnancieswithChronicAlcoholExposure JanineR.Hutson1,2,BrendaStade3,DenisC.Lehotay4,ChristineP.Collier5,6,BhushanM.Kapur1,7,8 * 1DivisionofClinicalPharmacologyandToxicology,HospitalforSickChildren,Toronto,Ontario,Canada,2InstituteofMedicalScience,UniversityofToronto,Toronto, Ontario, Canada, 3Department of Paediatrics, Keenan Research Centre, St. Michael’s Hospital, Toronto, Ontario, Canada, 4College of Medicine, University of Saskatchewan, Regina, Saskatchewan,Canada,5Department ofPathologyandMolecular Medicine, Queen’sUniversity, Kingston, EasternOntario, Canada, 6Kingston GeneralHospital,Kingston,EasternOntario,Canada,7DepartmentofClinicalPathology,SunnybrookHealthSciencesCentre,Toronto,Ontario,Canada,8Departmentof LaboratoryMedicineandPathobiology,FacultyofMedicine,UniversityofToronto,Ontario,Canada Abstract Background:Duringpregnancy,thedemandforfolicacidincreasessincethefetusrequiresthisnutrientforitsrapidgrowth andcellproliferation.Theplacentaconcentratesfolicacidintothefetalcirculation;asaresultthefetallevelsare2to4times higherthanthematernallevel.Animalandinvitrostudieshavesuggestedthatalcoholmayimpairtransportoffolicacid acrosstheplacentabydecreasingexpressionoftransportproteins.Weaimtodetermineiffolatetransfertothefetusis alteredinhumanpregnancieswithchronicalcoholconsumption. Methodology/PrincipalFindings:Serumfolatewasmeasuredinmaternalbloodandumbilicalcordbloodatthetimeof delivery in pregnancies with chronic and heavy alcohol exposure (n=23) and in non-drinking controls (n=24). In the alcohol-exposedpairs,thefetal:maternalserumfolateratiowas#1.0inoverhalf(n=14),whereasallbutoneofthecontrols were .1.0. Mean folate in cord samples was lower in the alcohol-exposed group than in the controls (33.15619.89 vs 45.91620.73,p=0.04). Conclusions/Significance: Our results demonstrate that chronic and heavy alcohol use in pregnancy impairs folate transport to the fetus. Altered folate concentrations within the pl