From Endosymbiont to Host-Controlled Organelle The Hijacking of Mitochondrial Protein Synthesis and Metabolism 英文参考文献.docVIP

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From Endosymbiont to Host-Controlled Organelle The Hijacking of Mitochondrial Protein Synthesis and Metabolism 英文参考文献.doc

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From Endosymbiont to Host-Controlled Organelle The Hijacking of Mitochondrial Protein Synthesis and Metabolism 英文参考文献

FromEndosymbionttoHost-Controlled Organelle:TheHijackingofMitochondrial ProteinSynthesisandMetabolism Toni Gabaldo′n¤*,Martijn A.Huynen NijmegenCenterforMolecularLifeSciences,CenterforMolecularandBiomolecularInformatics,UniversityofNijmegen,Nijmegen,TheNetherlands Mitochondriaareeukaryoticorganellesthatoriginatedfromtheendosymbiosisofanalpha-proteobacterium.Togain insightintotheevolutionofthemitochondrialproteomeasitproceededthroughthetransitionfromafree-livingcell toaspecializedorganelle,wecomparedareconstructedancestralproteomeofthemitochondrionwiththeproteomes ofalpha-proteobacteriaaswellaswiththemitochondrialproteomesinyeastandman.Overall,therehasbeenalarge turnover of the mitochondrial proteome during the evolution of mitochondria. Early in the evolution of the mitochondrion,proteinsinvolvedincellenvelopesynthesishavevirtuallydisappeared,whereasproteinsinvolvedin replication,transcription,celldivision,transport,regulation,andsignaltransductionhavebeenreplacedbyeukaryotic proteins. More than half of what remains from the mitochondrial ancestor in modern mitochondria corresponds to translation, including post-translational modifications, and to metabolic pathways that are directly, or indirectly, involved in energy conversion. Altogether, the results indicate that the eukaryotic host has hijacked the proto- mitochondrion,takingcontrolofitsproteinsynthesisandmetabolism. Citation:Gabaldo′nT,HuynenMA(2007)Fromendosymbionttohost-controlledorganelle:thehijackingofmitochondrialproteinsynthesisandmetabolism.PLoSComput Biol3(11):e219.doi:10.1371/journal.pcbi.0030219 modern mitochondrial proteomes and their inferred meta- bolic pathways. To reconstruct the proteome of the proto- Introduction Mitochondriaareorganellesthatarefoundinvirtuallyall eukaryotic cells. In addition to their role in energy conversion, mitochondria are involved in many processes from intermediate metabolism, such as synthesis of heme groups[1],steroids[2],aminoacids,andiron-sulphur (Fe-S) cl