From SOMAmer-Based Biomarker Discovery to Diagnostic and Clinical Applications A SOMAmer-Based, Streamlined Multiplex Proteomic Assay 英文参考文献.docVIP

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From SOMAmer-Based Biomarker Discovery to Diagnostic and Clinical Applications A SOMAmer-Based, Streamlined Multiplex Proteomic Assay 英文参考文献.doc

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From SOMAmer-Based Biomarker Discovery to Diagnostic and Clinical Applications A SOMAmer-Based, Streamlined Multiplex Proteomic Assay 英文参考文献

FromSOMAmer-BasedBiomarkerDiscoveryto DiagnosticandClinicalApplications:ASOMAmer-Based, StreamlinedMultiplexProteomicAssay StephanKraemer1,JonathanD.Vaught1,ChristopherBock1,LarryGold1,2,EvaldasKatilius1,TracyR. Keeney1,NancyKim1,NicholasA.Saccomano1*,SheriK.Wilcox1,DomZichi1,GlennM.Sanders1* 1SomaLogic,Inc.,Boulder,Colorado,UnitedStatesofAmerica,2DepartmentofMolecular,CellularandDevelopmentalBiology,UniversityofColoradoBoulder,Boulder, Colorado,UnitedStatesofAmerica Abstract Recently,wereportedaSOMAmer-based,highlymultiplexedassayforthepurposeofbiomarkeridentification.Toenable seamlesstransitionfromhighlymultiplexedbiomarkerdiscoveryassaystoaformatsuitableandconvenientfordiagnostic andlife-scienceapplications,wedevelopedastreamlined,plate-basedversionoftheassay.Theplate-basedversionofthe assayisrobust,sensitive(sub-picomolar),rapid,canbehighlymultiplexed(upwardsof60analytes),andfullyautomated. Wedemonstratethatquantificationbymicroarray-basedhybridization,Luminexbead-basedmethods,andqPCRareeach compatiblewithourplatform,furtherexpandingthebreadthofproteomicapplicationsforawideusercommunity. Citation:KraemerS,VaughtJD,BockC,GoldL,KatiliusE,etal.(2011)FromSOMAmer-BasedBiomarkerDiscoverytoDiagnosticandClinicalApplications:A SOMAmer-Based,StreamlinedMultiplexProteomicAssay.PLoSONE6(10):e26332.doi:10.1371/journal.pone.0026332 Editor:Jo¨rgD.Hoheisel,DeutschesKrebsforschungszentrum,Germany ReceivedSeptember14,2010;AcceptedSeptember25,2011;PublishedOctober17,2011 Copyright: ? 2011 Kraemer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: This work was funded bySomaLogic,Inc. Study design, data collection and analysis, decision topublish, andpreparationof thismanuscript were carriedoutbySomaLogicemployees. CompetingInterests:Theauthorshavereadthejournal’spolicyandhavethefollowingconflict: