Functional Polymorphism -31CG in the Promoter of BIRC5 Gene and Risk of Nasopharyngeal Carcinoma among Chinese 英文参考文献.docVIP

FunctionalPolymorphism-31C/GinthePromoterof BIRC5GeneandRiskofNasopharyngealCarcinoma amongChinese FuchaoMa1,2.,HongxingZhang1.,YunZhai1,WenfengHuang1,2,ChangZhao2,ShengqiuOu2 ,Hong Zhou2,WenzhaoYuan2,ZhifuWang1,HongxueWang1,2,WeiYue1,LixiaYu1,PeiyaoLi1,XiaXia1 ,Mi Cai1,YangZhang1,YingCui2,FuchuHe1,3,YilongMa2*,GangqiaoZhou1* 1StateKeyLaboratoryofProteomics,BeijingProteomeResearchCenter,BeijingInstituteofRadiationMedicine,Beijing,China,2AffiliatedCancerHospitalofGuangxi MedicalUniversity,Nanning,Guangxi,China,3InstitutesofBiomedicalSciences,FudanUniversity,Shanghai,China Abstract Background: Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5, also called as survivin) is a member of the inhibitor of apoptosis protein (IAP) family, which plays an important role in the occurrence and progression of cancer. Recently,apolymorphisminthepromoterofBIRC5,-31C/G(rs9904341),wasshowntoinfluenceBIRC5expression. Methods:Weexamined whetherthe-31C/Gwasrelatedtotheriskofdevelopingnasopharyngealcarcinoma (NPC)ina case-control population from Guangxi province in southern China, which consists of 855 patients with NPC and 1036 controls. This polymorphism was genotyped by TaqMan assay. The genetic associations with the occurrence and progressionofNPCwereestimatedbylogisticregression. Results:WeobservedastatisticallysignificantincreasedoccurrenceofNPCassociatedwiththeCCgenotype(oddsratio [OR],1.40;95%confidenceinterval[CI],1.13–1.73;P=0.0020)comparedwiththegenotypescontainingGallele(CG+GG genotype). However, no significant association was observed for the -31C/G with the severity of NPC (as measured by tumor-node-metastasisstagingsystem). Conclusion:Ourfindingssuggestthatthefunctionalpolymorphism-31C/GinthepromoterofBIRC5genemayplayarole inmediatingthesusceptibilitytoNPCamongChinese. Citation:MaF,ZhangH,ZhaiY,HuangW,ZhaoC,etal.(2011)FunctionalPolymorphism-31C/GinthePromoterofBIRC5GeneandRiskofNasopharyngeal CarcinomaamongChinese.PLoSONE6(2):e16748.doi:10.1371/journal.