Gait Analysis in Rats with Single Joint Inflammation Influence of Experimental Factors 英文参考文献.docVIP
- 1、本文档共12页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Gait Analysis in Rats with Single Joint Inflammation Influence of Experimental Factors 英文参考文献
GaitAnalysisinRatswithSingleJointInflammation:
InfluenceofExperimentalFactors
KristinaAngeby¨ Mo¨ller1*,SusanneKinert2,RolfSt?rkson3,Odd-GeirBerge1,4
1AstraZeneca RD So¨derta¨lje, CNSP iMed Science, So¨derta¨lje, Sweden, 2AstraZeneca RD So¨derta¨lje, Regulatory Affairs, So¨derta¨lje, Sweden, 3Department of
ImmunologyandTransfusionMedicine,HaukelandUniversityHospital,Bergen,Norway,4MultidisciplinaryPainCenter,UppsalaUniversityHospital,Uppsala,Sweden
Abstract
Disability and movement-related pain are major symptoms of joint disease, motivating the development of methods to
quantifymotorbehaviourinrodentjointpainmodels.Weusedobservationalscoringandautomatedmethodstocompare
weight bearing during locomotion and during standing after single joint inflammation induced by Freund’s complete
adjuvant(0.12–8.0mg/mL)orcarrageenan(0.47–30mg/mL).Automatedgaitanalysiswasbasedonvideocaptureofprints
generatedbylightprojectedintothelongedgeofthefloorofawalkway,producinganilluminatedimageofthecontact
areaofeachpawwithlightintensityreflectingthecontactpressure.Weightbearingwascalculatedasanarea-integrated
pawpressure,thatis,thelightintensityofallpixelsactivatedduringthecontactphaseofapawplacement.Automated
static weight bearing was measured with the Incapacitance tester. Pharmacological sensitivity of weight-bearing during
locomotion was tested in carrageenan-induced monoarthritis by administration of the commonly used analgesics
diclofenac, ibuprofen, and naproxen, as well as oxycodone and paracetamol. Observational scoring and automated
quantificationyieldedsimilarresults.Wefoundthatthewindowbetweencontrolratsandmonoarthriticratswasgreater
duringlocomotion.Theresponsewasmorepronouncedforinflammationintheankleascomparedtotheknee,suggesting
amethodologicaladvantageofusingthisinjectionsite.TheeffectsofbothFreund’scompleteadjuvantandcarrageenan
were concentration related, but Freund’s incomplete adjuvant was found to be as effective as lower, commonly used
concentrations of the co
您可能关注的文档
- Functional Characterization of a Newly Identified Group B Streptococcus Pullulanase Eliciting Antibodies Able to Prevent Alpha-Glucans Degradation 英文参考文献.doc
- Functional Characterization of Calcineurin Homologs PsCNA1PsCNB1 in Puccinia striiformis f. sp. tritici Using a Host-Induced RNAi System 英文参考文献.doc
- Functional Characterization of the Small Heat Shock Protein Hsp12p from Candida albicans 英文参考文献.doc
- Functional Characterization of Antibodies against Neisseria gonorrhoeae Opacity Protein Loops 英文参考文献.doc
- Functional Characterization of Transcription Factor Motifs Using Cross-species Comparison across Large Evolutionary Distances 英文参考文献.doc
- Functional Characterization of Aquaporin-4 Specific T Cells Towards a Model for Neuromyelitis Optica 英文参考文献.doc
- Functional Characterization of the Chlamydomonas reinhardtii ERG3 Ortholog, a Gene Involved in the Biosynthesis of Ergosterol 英文参考文献.doc
- Functional and Transcriptome Analysis Reveals an Acclimatization Strategy for Abiotic Stress Tolerance Mediated by Arabidopsis NF-YA Family Members 英文参考文献.doc
- Functional Characterizations of RIG-I to GCRV and ViralBacterial PAMPs in Grass Carp Ctenopharyngodon idella 英文参考文献.doc
- Functional Classification Using Phylogenomic Inference 英文参考文献.doc
文档评论(0)