Gene Expression Programs in Response to Hypoxia Cell Type Specificity and Prognostic Significance in Human Cancers 英文参考文献.docVIP
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Gene Expression Programs in Response to Hypoxia Cell Type Specificity and Prognostic Significance in Human Cancers 英文参考文献
o
PL SMEDICINE
GeneExpressionProgramsinResponse
toHypoxia:CellTypeSpecificityand
PrognosticSignificanceinHumanCancers
Jen-TsanChi1,2[,ZhenWang3[,DimitryS.A.Nuyten4,EdwinH.Rodriguez1,MarciE.Schaner1,AliSalim3,5,YunWang6,7
,
GunnarB.Kristensen6,Aslaug? Helland6,7,Anne-LiseB?rresen-Dale7,AmatoGiaccia5,MichaelT.Longaker3,TrevorHastie8,
GeorgeP.Yang3,9,MarcJ.vandeVijver4,PatrickO.Brown1,10*
1 Department of Biochemistry, Stanford University School of Medicine, Palo Alto, California, United States of America, 2 The Institute of Genome Sciences and Policy,
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America, 3 Department of Surgery,
StanfordUniversitySchoolofMedicine,PaloAlto,California,UnitedStatesofAmerica,4DiagnosticRadiationOncology,TheNetherlandsCancerInstitute,Amsterdam,The
Netherlands, 5DepartmentofRadiationOncology,StanfordUniversitySchoolofMedicine,PaloAlto,California,UnitedStatesofAmerica, 6DepartmentofGynecologic
Oncology,TheNorwegianRadiumHospital,Oslo,Norway,7DepartmentofGenetics,TheNorwegianRadiumHospital,Oslo,Norway,8HealthResearchandPolicy,Stanford
UniversitySchoolofMedicine,PaloAlto,California,UnitedStatesofAmerica,9PaloAltoVAHealthCareSystem,PaloAlto,StanfordUniversitySchoolofMedicine,PaloAlto,
California,UnitedStatesofAmerica,10HowardHughesMedicalInstitute,StanfordUniversitySchoolofMedicine,PaloAlto,California,UnitedStatesofAmerica
Competing Interests: POBisCo-
Founder ofthePublic Library of
ScienceandisonitsBoardofDirectors.
ABSTRACT
Background
AuthorContributions:JTC,ZW,and
POBconceivedanddesignedthe
experiments.JTC,ZW,EHR,MES,and
ASperformedtheexperiments.JTC,
ZW,DSAN,MES,YW,GBK,AH,ALBD,
AG,MTL,TH,GPY,MJvdV,andPOB
analyzedthedata.JTC,ZW,EHR,and
POBwrotethepaper.
Inadequate oxygen (hypoxia) triggers a multifaceted cellular response that has important
roles in normal physiology and in many human diseases. A transcription factor, hypoxia-
induciblefactor(HI
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