Genetic Association Studies in Lumbar Disc Degeneration A Systematic Review 英文参考文献.docVIP

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Genetic Association Studies in Lumbar Disc Degeneration A Systematic Review 英文参考文献.doc

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Genetic Association Studies in Lumbar Disc Degeneration A Systematic Review 英文参考文献

Review GeneticAssociationStudiesinLumbarDisc Degeneration:ASystematicReview PasiJ.Eskola1,SusannaLemmela¨2,PerKjaer3,4,5,SvetlanaSolovieva2,MinnaMa¨nnikko¨1, NielsTommerup5,AllanLind-Thomsen5,KirstiHusgafvel-Pursiainen2,KennethM.C.Cheung6, DannyChan7,DinoSamartzis6*.,JaroKarppinen 2,8 . * 1OuluCenterforCell–MatrixResearch,BiocenterandDepartmentofMedicalBiochemistryandMolecularBiology,UniversityofOulu,Oulu,Finland,2FinnishInstituteof Occupational Health,Health and Work Ability,and Disability PreventionCentre, Helsinki, Finland, 3ResearchDepartment, Spine CentreofSouthernDenmark,Part of ClinicalLocomotionNetwork,HospitalLillebaelt,InstituteofRegionalHealthResearch,UniversityofSouthernDenmark,Middelfart,Denmark,4InstituteofSportsScience andClinicalBiomechanics,PartofClinicalLocomotionNetwork,UniversityofSouthernDenmark,Odense,Denmark,5WilhelmJohannsenCentreForFunctionalGenome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark, 6Department of Orthopaedics and Traumatology, UniversityofHongKong,Pokfulam,HongKong,SAR,China,7DepartmentofBiochemistry,UniversityofHongKong,Pokfulam,HongKong,SAR,China,8Instituteof ClinicalMedicine,DepartmentofPhysicalandRehabilitationMedicine,UniversityofOuluandOuluUniversityHospital,Oulu,Finland degeneration of the lumbar spine is a clear contributing factor [7–13]. Abstract: Objective: Low back pain is associated with lumbardiscdegeneration,whichismainlyduetogenetic predisposition.Theobjectiveofthisstudywastoperform a systematic review to evaluate genetic association studies in lumbar disc degeneration as defined on magneticresonanceimaging(MRI)inhumans. Disc degeneration is characterized as morphological and biochemical changes of the disc. Magnetic resonance imaging (MRI) is the current gold standard to assess the integrity of the intervertebral disc [14]. Degenerative changes on imaging are generallybasedondecreasedsignalintensity(representinglossof hydration), reduced disc height,