Genetic Basis for Dosage Sensitivity in Arabidopsis thaliana 英文参考文献.docVIP

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2017-05-11 发布于上海
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Genetic Basis for Dosage Sensitivity in Arabidopsis thaliana 英文参考文献.doc

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Genetic Basis for Dosage Sensitivity in Arabidopsis thaliana 英文参考文献

GeneticBasisforDosageSensitivity inArabidopsisthaliana Isabelle M.Henry¤a,Brian P.Dilkes¤b,Luca Comai¤b* DepartmentofBiology,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica Aneuploidy,therelativeexcessordeficiencyofspecificchromosometypes,resultsingenedosageimbalance.Plants canproduceviableandfertileaneuploidindividuals,whilemostanimalaneuploidsareinviableordevelopmentally abnormal. The swarms of aneuploid progeny produced by Arabidopsis triploids constitute an excellent model to investigate the mechanisms governing dosage sensitivity and aneuploid syndromes. Indeed, genotype alters the frequencyofaneuploidtypeswithintheseswarms.Recombinantinbredlinesthatwerederivedfromatriploidhybrid segregated into diploid and tetraploid individuals. In these recombinant inbred lines, a single locus, which we call SENSITIVETODOSAGEIMBALANCE(SDI),exhibitedsegregationdistortioninthetetraploidsubpopulationonly.Recent progressinquantitativegenotypingnowallowsmolecularkaryotypingandgeneticanalysisofaneuploidpopulations. Inthisstudy,weinvestigatedthecausesoftheploidy-specificdistortionatSDI.Allelefrequencywasdistortedinthe aneuploid swarms produced by the triploid hybrid. We developed a simple quantitative measure for aneuploidy lethality and using this measure demonstrated that distortion was greatest in the aneuploids facing the strongest viabilityselection.Whentriploidswerecrossedtoeuploids,theprogeny,whichlacksevereaneuploids,exhibitedno distortionatSDI.GeneticcharacterizationofSDIintheaneuploidswarmidentifiedamechanismgoverninganeuploid survival,perhapsbybufferingtheeffectsofdosageimbalance.Assuch,SDIcouldincreasethelikelihoodofretaining genomicrearrangementssuchassegmentalduplications.Additionally,inspecieswheretriploidsarefertile,aneuploid survival would facilitate gene flow between diploid and tetraploid populations via a triploid bridge and prevent polyploidspeciation.Ourresultsdemonstratethatpositionalcloningoflociaffectingtraitsinpopulationscontaining ploidy