Genetic Markers Enhance Coronary Risk Prediction in Men The MORGAM Prospective Cohorts 英文参考文献.docVIP
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Genetic Markers Enhance Coronary Risk Prediction in Men The MORGAM Prospective Cohorts 英文参考文献
GeneticMarkersEnhanceCoronaryRiskPredictionin
Men:TheMORGAMProspectiveCohorts
MariaF.Hughes1*,OlliSaarela2,JanStritzke3,FrankKee1,KaisaSilander2,4,NormanKlopp5,
JukkaKontto2,JuhaKarvanen2,ChristinaWillenborg3,VeikkoSalomaa2,JarmoVirtamo2,
PhillippeAmouyel6,DominiqueArveiler7,JeanFerrie`res8,Per-GunnerWiklund9,JensBaumert5,
BarbaraThorand5,PatrickDiemert3,David-AlexandreTre′goue¨t10,ChristianHengstenberg11,
AnnettePeters5,AlunEvans1,WolfgangKoenig12,JeanetteErdmann3,NileshJ.Samani13,
KariKuulasmaa2.,HeribertSchunkert3.
1UKCRC Centre of Excellence for Public Health, Queens University of Belfast, Belfast, Northern Ireland, United Kingdom, 2Department of Chronic Disease Prevention,
NationalInstituteforHealthandWelfare,Helsinki,Finland,3Universita¨tzuLu¨beck,Lu¨beck,Germany,4FIMM,InstituteforMolecularMedicineFinland,UniversityofHelsinki,
Helsinki,Finland,5InstituteofEpidemiologyII,HelmholtzZentrumMu¨nchen,Mu¨nchen,Germany,6INSERMU744,Lille,France,7DepartmentofEpidemiologyandPublic
Health,EA3430,UniversityofStrasbourg,Strasbourg,France,8INSERMU558,ToulouseUniversitySchoolofMedicine,Toulouse,France,9DepartmentofPublicHealthand
ClinicalMedicine,Umea?University,Umea?,Sweden,10INSERMUMRS937,UniversityPierreetMarieCurrie,Paris,France,11DepartmentofInternalMedicineandCardiology,
UniversityofRegensburg,Regensburg,Germany,12DepartmentofInternalMedicineII–Cardiology,UniversityofUlm,Ulm,Germany,13DepartmentofCardiovascular
Sciences,UniversityofLeicester,andLeicesterNIHRBiomedicalResearchUnitinCardiovascularDisease,GlenfieldHospital,Leicester,UnitedKingdom
Abstract
Background:Moreaccuratecoronaryheartdisease(CHD)prediction,specificallyinmiddle-agedmen,isneededtoreduce
theburdenofdiseasemoreeffectively.WehypothesisedthatamultilocusgeneticriskscorecouldrefineCHDprediction
beyondclassicriskscoresandobtainmorepreciseriskestimatesusingaprospectivecohortdesign.
Methods:UsingdatafromnineprospectiveEuropeancohorts,including26,221men,weselectedinacase-cohortsetting
4,818healthymenatbaselin
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