Genetic Polymorphisms of Estrogen Receptors α and β and the Risk of Developing Prostate Cancer 英文参考文献.docVIP

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Genetic Polymorphisms of Estrogen Receptors α and β and the Risk of Developing Prostate Cancer 英文参考文献.doc

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Genetic Polymorphisms of Estrogen Receptors α and β and the Risk of Developing Prostate Cancer 英文参考文献

GeneticPolymorphismsofEstrogenReceptorsaandb andtheRiskofDevelopingProstateCancer YoungKwangChae1,2*,Han-YaoHuang2,3,PaulStrickland2,SandraC.Hoffman2,KathyHelzlsouer2,4 1Department ofMedicine,Albert EinsteinMedicalCenter,Philadelphia,Pennsylvania; UnitedStatesofAmerica, 2Department ofEpidemiology, BloombergSchool of PublicHealth,JohnsHopkinsUniversity,Baltimore,Maryland,UnitedStatesofAmerica,3OutcomesResearchandManagement,MerckCo.,WestPoint,Pennsylvania, UnitedStatesofAmerica,4ThePreventionandResearchCenter,MercyMedicalCenter,Baltimore,Maryland,UnitedStatesofAmerica Abstract Estrogen may be involved in the development of prostate cancer. The association between genetic polymorphisms of estrogen receptors a (ESR1) and b (ESR2) and prostate cancer risk was examined in a nested case-control study in WashingtonCounty,Maryland.Incidentprostatecancercases(n=269)werematchedtooneortwocontrols(n=440)by age,sex,race,anddateofblooddonation.Associationsbetweenestrogenreceptorgenotypesordietaryintakeandthe developmentofprostatecancerwereexaminedinconditionallogisticregressionmodels.Resultsfromthisstudyshowed thatsixsinglebase-pairpolymorphisms(SNPs)ofESR1(rs1801132,rs2077647,rs746432,rs2273206,rs851982,rs2228480) andfourSNPsofESR2(rs4986938,rs928554,rs8018687,rsnumbernotavailableforESR25696bp39ofSTPA.G)werenot significantly associated with prostate cancer risk, either by allelic or genotypic frequencies. However, an interactive associationwithBMIwasobservedintherelationshipbetweenprostatecancerriskandgenotypesofESR238bp39ofSTP G.A (rs4986938) (p=0.031). An interaction between intake level of phytoestrogen and genotypes of ESR1 Ex1-192G.C (rs746432)andbetweenintakelevelofphytoestrogenandgenotypesofESR1Ex8+229G.A(rs2228480)andriskofprostate cancerwasobserved(p=0.0009andp=0.044,respectively).Inconclusion,selectedgeneticpolymorphismsofESR1and ESR2,overall,werenotassociatedwithprostatecancerrisk.However,avariationinriskbyBMIandphytoestrogenintake wasimplicated. Citation:ChaeYK,Hu