Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans A Short Report 英文参考文献.docVIP

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Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans A Short Report 英文参考文献.doc

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Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans A Short Report 英文参考文献

Genome-WideAssociationAnalysisofIncidentCoronary HeartDisease(CHD)inAfricanAmericans:AShortReport MajaBarbalic1,AlexP.Reiner2,3,ChunyuanWu3,JamesE.Hixson1,NoraFranceschini4,CharlesB. Eaton5,GerardoHeiss4,DavidCouper6,ThomasMosley7,EricBoerwinkle1* 1HumanGeneticsCenter,UniversityofTexasHealthScienceCenteratHouston,Houston,Texas,UnitedStatesofAmerica,2DepartmentofEpidemiology,Universityof Washington,Seattle,Washington,UnitedStatesofAmerica,3DivisionofPublicHealthSciences,FredHutchinsonCancerResearchCenter,Seattle,Washington,United States of America, 4Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America, 5Center for Primary Care and Prevention, Alpert Medical School, Brown University, Providence, Rhode Island, United States of America, 6Department of Biostatistics, University of North Carolina, ChapelHill,NorthCarolina,UnitedStatesofAmerica,7DepartmentofMedicine,UniversityofMississippiMedicalCenter,Jackson,Mississippi,UnitedStatesofAmerica Abstract AfricanAmericanshavethehighestrateofmortalityduetocoronaryheartdisease(CHD).Althoughmultiplelocihavebeen identified influencing CHD risk in European-Americans using a genome-wide association (GWAS) approach, no GWAS of incidentCHDhasbeenreportedforAfricanAmericans.WeperformedaGWASforincidentCHDeventscollectedduring19 yearsoffollow-upin2,905AfricanAmericansfromtheAtherosclerosisRiskinCommunities(ARIC)study.Weidentifieda genome-widesignificantSNP(rs1859023,MAF=31%)locatedat7q21nearthePFTK1gene(HR=0.57,95%CI0.46to0.69, p=1, which replicated in an independent sample of over 8,000 African American women from the Women’s HealthInitiative(WHI)(HR=0.81,95%CI0.70to0.93,p=0.005).PFTK1encodesaserine/threonine-proteinkinase,PFTAIRE- 1,thatactsasacyclin-dependentkinaseregulatingcellcycleprogressionandcellproliferation.Thisisthefirstfindingof incidentCHDlocusidentifiedbyGWASinAfricanAmericans. Citation:BarbalicM,ReinerAP,WuC,HixsonJE,FranceschiniN,etal.(2011)Genome-Wid