Genetic Variation in Selenoprotein Genes, Lifestyle, and Risk of Colon and Rectal Cancer 英文参考文献.docVIP

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Genetic Variation in Selenoprotein Genes, Lifestyle, and Risk of Colon and Rectal Cancer 英文参考文献.doc

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Genetic Variation in Selenoprotein Genes, Lifestyle, and Risk of Colon and Rectal Cancer 英文参考文献

GeneticVariationinSelenoproteinGenes,Lifestyle,and RiskofColonandRectalCancer MarthaL.Slattery1*,AbbieLundgreen1,BillWelbourn2,ChristopherCorcoran2,RogerK.Wolff1 1DepartmentofInternalMedicine,UniversityofUtahHealthSciencesCenter,SaltLakeCity,Utah,UnitedStatesofAmerica,2DepartmentofMathematicsandStatistics, UtahStateUniversity,Logan,Utah,UnitedStatesofAmerica Abstract Background: Associations between selenium and cancer have directed attention to role of selenoproteins in the carcinogenicprocess. Methods:Weuseddatafromtwopopulation-basedcase-controlstudiesofcolon(n=1555cases,1956controls)andrectal (n=754cases,959controls)cancer.WeevaluatedtheassociationbetweengeneticvariationinTXNRD1,TXNRD2,TXNRD3, C11orf31(SelH),SelW,SelN1,SelS,SepX,andSeP15withcolorectalcancerrisk. Results: After adjustment for multiple comparisons, several associations were observed. Two SNPs in TXNRD3 were associatedwithrectalcancer(rominantOR1.4295%CI1.16,1.74pACT0.0036andrs9637365recessive0.70 95%CI0.55,0.90pACT0.0208).FourSNPsinSepN1wereassociatedwithrectalcancer(recessiveOR1.3095%CI 1.04,1.63 pACT 0.0410; rs2072749 GGvsAA OR 0.53 95% CI 0.36,0.80 pACT 0.0159; rs4659382 recessive OR 0.58 95% CI 0.39,0.86pACT0.0247;rs718391dominantOR0.7695%CI0.62,0.94pACT0.0300).Interactionbetweenthesegenesand exposures that could influence these genes showed numerous significant associations after adjustment for multiple comparisons.TwoSNPsinTXNRD1andfourSNPsinTXNRD2interactedwithaspirin/NSAIDtoinfluencecoloncancer;one SNPinTXNRD1,twoSNPsinTXNRD2,andoneSNPinTXNRD3interactedwithaspirin/NSAIDstoinfluencerectalcancer.Five SNPsinTXNRD2andoneinSelS,SeP15,andSelW1interactedwithestrogentomodifycoloncancerrisk;oneSNPinSelW1 interacted with estrogen to alter rectal cancer risk. Several SNPs in this candidate pathway influenced survival after diagnosiswithcoloncancer(SeP15andSepX1increasedHRR)andrectalcancer(SepX1increasedHRR). Conclusions:Findingssupportanassociationbetweenselenoproteingenesandco