Health Benefits of Universal Influenza Vaccination Strategy 英文参考文献.docVIP

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Health Benefits of Universal Influenza Vaccination Strategy 英文参考文献.doc

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Health Benefits of Universal Influenza Vaccination Strategy 英文参考文献

Perspective Health Benefits of Universal Influenza Vaccination Strategy Cécile Viboud , Mark Miller * M ost countries in Europe and North America target influenza immunization databases and influenza laboratory surveillance data were used to estimate trends in influenza-related mortality, hospitalization, and visits to emergency departments and doctors’ offices. Linked Research Article This Perspective discusses the following new studies published inPLoS Medicine: Kwong JC, Stukel TA, Lim J, McGeer AJ, Upshur REG, et al. (2008) The effect of universal influenza immunization on mortality and health care use. PLoS Med 5(10): e211. doi:10.1371/journal. pmed.0050211 Comparing influenza-related mortality and health care use between Ontario and other Canadian provinces, Jeffrey Kwong and colleagues find evidence that Ontario’s universal vaccination program has reduced the burden of influenza. van den Dool C, Bonten MJM, Hak E, Heijne JCM, Wallinga J (2008) The effects of influenza vaccination of health care workers in nursing homes: Insights from a mathematical model. PLoS Med 5(10): e200. doi:10.1371/journal.pmed.0050200 Using a mathematical model to to persons at highest risk for complications, including seniors 65 years and older, those with certain chronic illnesses, and young children. Despite increases in vaccination rates in these high-risk groups over the last few decades, morbidity and mortality from influenza remain high. Study Results The authors found that the influenza burden decreased as vaccination rates increased across all age groups in Ontario, with a 49%–59% decline for various outcomes (p 0.002), relative to other provinces. Comparisons across provinces showed that there was also a convincing coverage–response relationship among people under 65 years, in that the largest vaccine uptakes corresponded to the greatest reductions in disease burden. Disappointing Results of Targeted Influenza Vaccination Strategies Seniors suffer about 90% of the influen